PMID: 9185913Jun 1, 1997Paper

Malignant mesothelioma metastatic to the skin, presenting as inflammatory carcinoma

The American Journal of Dermatopathology
V G PrietoM Varghese

Abstract

We report a 50-year-old man with a history of malignant pleural mesothelioma diagnosed 1 year previously and treated with pneumonectomy and radiotherapy who presented with an erythematous eruption on the left chest wall. A skin biopsy showed a proliferation of malignant epithelioid cells lining irregular clefts in the dermis. Some groups of cells were observed filling vascular lumina. Immunohistochemically, the tumor cells expressed cytokeratins (with antibodies AE1/AE3, MNF 116, and CAM 5.2), and epithelial membrane antigen (EMA), and were negative with Ulex europaeus (UE) and for carcinoembryonic antigen (CEA), CD34, CD15 (with LeuM1 antibody), and factor VIII-related antigen (FVIIIra). The histologic features and immunohistochemical profile were comparable to those observed in the primary pleural mesothelioma. This is the first reported case in which malignant mesothelioma metastatic to the skin presented as "inflammatory carcinoma." Although a very uncommon presentation, mesothelioma should be considered in the differential diagnosis of erythematous eruptions on the chest.

References

Dec 1, 1992·Journal of Cutaneous Pathology·P L DuttD L Page
Aug 1, 1990·The American Journal of Dermatopathology·A J MarrogiD J Cruz
Nov 1, 1989·Journal of the American Academy of Dermatology·R K BerkowitzM E Grossman
Jun 1, 1985·Journal of Cutaneous Pathology·P H McKee
Jan 1, 1971·Thorax·F Whitwell, R M Rawcliffe
Feb 1, 1966·Cancer·I M Reingold
Oct 1, 1983·Archives of Dermatology·N G Ordóñez, J L Smith
Oct 1, 1995·Journal of the American Academy of Dermatology·R A Schwartz
Nov 1, 1994·Histopathology·R J PrescottN Y Haboubi
Mar 1, 1995·The American Journal of Surgical Pathology·R A Erlandson, J Rosai
Aug 1, 1993·Journal of the American Academy of Dermatology·D P LookingbillK F Helm
Jan 1, 1995·Urologia Internationalis·T Umekawa, T Kurita
Nov 1, 1961·Dermatologica·A H MEHREGAN

❮ Previous
Next ❯

Citations

Dec 27, 2006·Pathology Oncology Research : POR·Lina PappaVassiliki Malamou-Mitsi
Aug 2, 2007·The American Journal of Dermatopathology·Trevor W Beer, Peter J Heenan
Nov 11, 2009·World Journal of Surgical Oncology·Alaaeldeen M ElbahaieNeville G Davidson
Sep 7, 1999·European Journal of Cancer Care·S L Cheeseman, M R Ranson
Nov 24, 2004·Thoracic Surgery Clinics·Lambros Zellos, David C Christiani
Jul 9, 2004·Journal of Cutaneous Pathology·Sherry ShiehRichard T Cheney
Sep 26, 2003·Journal of Cutaneous Pathology·David S CassarinoKevin J Shannon
Feb 26, 2004·European Journal of Cancer Care·N KrishnarajH R Gribbin
Jun 11, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·C S L MüllerW Tilgen
Jul 20, 1999·Dermatologic Clinics·A R Hudson, B R Smoller
Oct 24, 2017·The American Journal of Dermatopathology·Nikolai KlebanovHensin Tsao
Aug 12, 2017·Journal of Cutaneous Pathology·Rachel Elizabeth WardMatthew Kuhar
Feb 20, 2016·The American Journal of Dermatopathology·Patricia HispánGloria Peiró
Dec 2, 2020·Journal of Cutaneous Pathology·Katrina CollinsPhyu P Aung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Dermatology
R A Schwartz
Journal of Cutaneous Pathology
David S CassarinoKevin J Shannon
Journal of Surgical Oncology
L E EdstromT R DeMeester
Journal of the American Academy of Dermatology
Antonio MaioranaGiulio Rossi
© 2021 Meta ULC. All rights reserved