Malignant mixed mesodermal ovarian tumor treatment and prognosis: a 20-year experience

Gynecologic Oncology
T LeM S Heywood

Abstract

Mixed mesodermal sarcoma of the ovary is a rare clinical entity. To review the epidemiology, prognostic factors, and treatment results related to primary ovarian sarcoma at our center, a retrospective chart review of all patients referred for ovarian cancer was carried out from 1974 to 1994. Cases with confirmed pathologic diagnosis of primary mixed mesodermal ovarian sarcomas were selected, forming the present study group. Thirty-six charts were identified. The median age at presentation was 67.5 years. Findings at laparotomy demonstrated extraovarian metastasis in 33/35 patients. Total abdominal hysterectomy and bilateral salpingo-oophorectomy +/- omentectomy were performed in 34 patients, with 22 patients left with macroscopic residual disease after surgery. Follow-up adjuvant chemotherapy consisting of cisplatin and doxorubicin was administered to 29/36 patients. Follow-ups ranged from 1 to 11 years with a median of 2 years. As with epithelial ovarian cancer, residual disease after initial surgery is an important prognostic factor. Thirteen patients had a second-look laparotomy. Five patients were positive for disease. Eight patients, one of whom recurred, were histologically negative. The patients with positive second-look...Continue Reading

Citations

Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A-C. HellströmF. Pettersson
Jan 14, 2012·Cancer Biotherapy & Radiopharmaceuticals·Ruby MeredithAlbert LoBuglio
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J E MokJ H Nam
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GariG Stanimir
Mar 17, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M S ManoA Awada
Oct 4, 2012·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jonathan S BerekMichael Friedlander
Mar 23, 2011·Gynecologic Oncology·J Alejandro Rauh-HainMarcela G del Carmen
Nov 29, 2005·Obstetrics and Gynecology Clinics of North America·Hamid SayarClaire F Verschraegen
Oct 5, 2015·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jonathan S BerekMichael Friedlander
May 21, 2003·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Perapong InthasornJonathan Carter
Jun 20, 2013·Obstetrics and Gynecology International·Amelia M JerniganPedro F Escobar
Jun 8, 2002·Gynecologic Oncology·Linda R DuskaArlan F Fuller
Nov 7, 2000·Gynecologic Oncology·A S SitR P Edwards
Oct 12, 2018·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jonathan S BerekMichael Friedlander
Apr 25, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·D-A SilasiP E Schwartz
May 1, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R AthavaleR Naik
Jun 10, 2004·Pathology Oncology Research : POR·Gábor VermesFerenc Bánhidy
Feb 24, 2006·Current Opinion in Obstetrics & Gynecology·Roberto Navarini, Rafael Luis Pineda
Feb 8, 2011·Archives of Gynecology and Obstetrics·Berna Bozkurt DumanVehbi Ercolak
Jan 13, 2016·American Journal of Clinical Oncology·Rachel M WhynottJohn P Geisler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.