Malignant peritoneal cytology and increased mortality risk in stage I non-endometrioid endometrial cancer.

Gynecologic Oncology
Koji MatsuoMaximilian Klar

Abstract

To examine the survival of women with stage I non-endometrioid endometrial cancer with malignant peritoneal cytology. A retrospective observational cohort study was conducted to examine the National Cancer Institute's Surveillance, Epidemiology, and End Results Program from 2010 to 2016. Women with stage I serous, clear cell, carcinosarcoma, undifferentiated, and mixed endometrial cancer with known peritoneal cytology results at hysterectomy were examined (N = 4506). Propensity score inverse probability of treatment weighting was used to balance the measured covariates, and survival outcomes were assessed according to peritoneal cytology results. Malignant peritoneal cytology was reported in 401 (8.9%) women. In multivariable analysis, older age, serous histology, and large tumors were associated with an increased likelihood of malignant peritoneal cytology (all, P < 0.05). In a propensity score weighted model, malignant peritoneal cytology was associated with a nearly two-fold increase in all-cause mortality risk compared to negative peritoneal cytology (5-year rates, 63.4% versus 80.2%, hazard ratio 2.18, 95% confidence interval 1.78-2.66). In sensitivity analyses, malignant peritoneal cytology was associated with decreased o...Continue Reading

Citations

Feb 9, 2021·Gynecologic Oncology·Masataka TakenakaAikou Okamoto
Sep 24, 2020·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Koji MatsuoMaximilian Klar
Oct 17, 2020·Annals of Surgical Oncology·Koji MatsuoLynda D Roman
Jun 13, 2021·Journal of Surgical Oncology·Koji MatsuoLynda D Roman
Aug 24, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Hsiu-Jung TungChyong-Huey Lai

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