Malignant perivascular epithelioid tumor of the vagina: Report of a rare case with brief review of literature

Diagnostic Cytopathology
Ruchika GuptaSanjay Gupta

Abstract

Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors with immunohistochemical co-expression of melanocytic and myoid markers. Vaginal PEComas have been described in only nine cases so far. We describe the case of a 65-year-old female with a large growth in the left lateral vaginal wall. Biopsy imprint smears showed dispersed tumor cells with anisonucleosis, multinucleation, and bizarre forms, suggestive of a malignant tumor. Histopathology, however, showed perivascular arrangement of clear epithelioid cells, focal necrosis, intracellular brown pigment in few cells, and mitotic activity at 2 to 3 per 50 high power fields. Immunohistochemical positivity for vimentin, HMB-45, S-100 protein, desmin, and MyoD1 assisted in rendering a final pathological diagnosis of malignant PEComa of the vagina. Further work-up revealed metastatic deposits in liver and retroperitoneal lymph nodes. PEComa arising in vagina is an unusual phenomenon with the malignant variant being an extremely rare tumor. Awareness of the characteristic morphology and utilization of a panel of immunohistochemical stains are mandatory to be able to make a precise diagnosis and appropriate prognostication.

References

Mar 27, 2004·The American Journal of Surgical Pathology·Elvio G SilvaAnais Malpica
Oct 4, 2005·Annals of Diagnostic Pathology·Karthik KalyanasundaramRama Mani
Jan 2, 2007·Advances in Anatomic Pathology·Guido MartignoniFranco Bonetti
Mar 6, 2007·Journal of Pediatric Surgery·Lin Yin OngChan Hon Chui
Oct 31, 2008·The American Journal of Surgical Pathology·William R SukovAndrew L Folpe
Apr 28, 2009·Archives of Pathology & Laboratory Medicine·Henry B Armah, Anil V Parwani
Sep 17, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M A RettenmaierB H Goldstein
Dec 18, 2013·Pathology, Research and Practice·Valentina NatellaLuigi Insabato
Jan 15, 2014·The American Journal of Surgical Pathology·John Kenneth SchoolmeesterMarisa R Nucci

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Citations

Oct 26, 2020·Genes, Chromosomes & Cancer·Jennifer A Bennett, Esther Oliva

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