Malignant phyllodes tumor of the breast with hypoglycemia: report of a case

Japanese Journal of Clinical Oncology
T KataokaS Nomura

Abstract

A surgically resected case of giant malignant phyllodes tumor of the breast associated with a hypoglycemic attack is reported. A 54-year-old woman was referred to our hospital with loss of consciousness and a huge chest wall tumor. She was diagnosed as having a malignant phyllodes tumor by core needle biopsy and underwent palliative simple mastectomy because lung metastasis was detected on computed tomography and by other imaging modalities on admission. The preoperative laboratory data revealed a very low fasting blood sugar level of 37 mg/dl. After removal of the tumor, the blood sugar level gradually normalized (90-100 mg/dl) and the plasma insulin-like growth factor-II (IGF-II) level promptly decreased. The IGF-II level of tumor extracts was high (2500 ng/g wet weight) and the majority of atypical cells stained positively for IGF-II immunohistochemically. These findings suggested that the patient's hypoglycemia was associated with IGF-II produced by a giant malignant phyllodes tumor that consumed glucose.

Citations

Mar 5, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Naoki HinoMasaru Tsuyuguchi
May 19, 2009·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ellen M ChungLeonard M Glassman
Sep 17, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Abid IrshadBeata Panzegrau
Oct 18, 2007·The British Journal of Radiology·A M ScaraneloF P O'Malley
Jan 24, 2007·Clinical Breast Cancer·Laila SamiianIrene Wapnir
Jun 23, 2016·Indian Journal of Anaesthesia·Sudivya Prashast Sharma, Atul Prabhakar Kulkarni
Dec 17, 2017·Medicine·Qinqin WangYutao Lei

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