Malignant Pleural Mesothelioma Outcomes in the Era of Combined Platinum and Folate Antimetabolite Chemotherapy

Lung Cancer International
Mathieu D Saint-PierrePaul Wheatley-Price

Abstract

Introduction. Malignant pleural mesothelioma (MPM) is associated with a poor prognosis. Palliative platinum-based chemotherapy may help to improve symptoms and prolong life. Since 2004, the platinum is commonly partnered with a folate antimetabolite. We performed a review investigating if survival had significantly changed before and after the arrival of folate antimetabolites in clinical practice. Methods. All MPM patients from January 1991 to June 2012 were identified. Data collected included age, gender, asbestos exposure, presenting signs/symptoms, performance status, histology, stage, bloodwork, treatment modalities including chemotherapy, and date of death or last follow-up. The primary endpoint was overall survival. Cox models were applied to determine variables associated with survival. Results. There were 245 patients identified. Median overall survival for all patients was 9.4 months. After multivariate analysis, performance status, stage, histology, leucocytosis, and thrombophilia remained independently associated with survival. Among all patients who received chemotherapy, there was no difference in overall survival between the periods before and after folate antimetabolite approval: 14.2 versus 13.2 months (P = 0.3...Continue Reading

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Citations

Jun 18, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marco TomasettiLory Santarelli
Jul 21, 2017·Journal of Medical Imaging and Radiation Oncology·Farshad ForoudiMorikatsu Wada
Apr 25, 2021·Clinical Lung Cancer·Abdullah NasserPaul Wheatley-Price

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