Malignant solitary fibrous tumors of the head and neck: a clinicopathological study of nine consecutive patients

Oral Oncology
X J YangZ Y Zhang

Abstract

Malignant solitary fibrous tumor (MSFT) is one of the angiosarcomas arising from or resembling the components of blood vessels. Because of its rarity, the diagnosis is difficult. Between 1998 and 2008, 24 patients were diagnosed as having hemangiopericytomas (16) and solitary fibrous tumors (8). Nine of them were confirmed to be MSFT and treated at the Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. All patients were treated with surgery as the primary modality. Eight patients received postoperative adjuvant radiation therapy. The average follow-up duration was 4.6 years (range: 6 months-10 years). Of the nine patients reviewed in this study, three died of locoregional or distant metastasis, six survived 6 months-6 years (four survived over 4 years). The size of primary tumor, the number of mitoses per 10 high powered fields and cervical lymph node metastasis seemed to be correlated with poor prognosis in MSFT patients, although the small number of patients did not permit the performance of statistical analysis.

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Citations

Dec 3, 2014·Pathology, Research and Practice·Denise Hélen Imaculada Pereira de OliveiraLélia Maria Guedes Queiroz
Aug 2, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Masashi MigitaHitoshi Ohata
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Jan 16, 2019·Ocular Oncology and Pathology·Lorenzo RinaldoAditya Raghunathan
Mar 7, 2020·American Journal of Clinical Pathology·Everton Freitas de MoraisRoseana de Almeida Freitas
Jun 5, 2020·Ophthalmic Plastic and Reconstructive Surgery·Chad H JacksonGerald J Harris
Jul 13, 2021·Head and Neck Pathology·Jaylou M Velez TorresAndrew E Rosenberg

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