Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study

Journal of Pediatric Surgery
Marc DirixL W Ernest van Heurn

Abstract

The risk of malignant transformation of sacrococcygeal teratoma (SCT) and of presacral teratoma in Currarino syndrome (CS) may differ despite the similar position and appearance. Malignant transformation and teratoma recurrence were assessed in a national retrospective comparative analysis of 205 SCT and 16 CS patients treated in one of the six pediatric surgical centers in the Netherlands between January 1981 and December 2010. The malignancy free survival of patients with SCT was lower than for patients with a presacral teratoma associated with CS (80% and 58% after one and two years in SCT versus 100% after two years in CS, p=0.017) CONCLUSIONS: In SCT, malignancy and recurrence risk are high. Therefore, early and complete resection is mandatory. Our data show that the risk of malignant transformation of a presacral teratoma in CS is small.

References

Jun 1, 1974·Journal of Pediatric Surgery·R P AltmanJ R Lilly
Aug 1, 1981·AJR. American Journal of Roentgenology·G CurrarinoT Votteler
Apr 1, 1996·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·J KöchlingW R Lanksch
Aug 3, 2000·Journal of Medical Genetics·S A LynchS Lindsay
Sep 11, 2004·Journal of Pediatric Surgery·G MartuccielloV Jasonni
Aug 6, 2005·Journal of Pediatric Surgery·Pieter J EmansL W Ernest van Heurn
Jan 18, 2006·Journal of Pediatric Surgery·Celia CrétolleClaire Nihoul-Fékété
Oct 24, 2006·The British Journal of Surgery·J P M DerikxL W E van Heurn
May 18, 2010·Pediatric Surgery International·Atsushi YoshidaSpencer Beasley
May 19, 2010·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S A L BartelsH A Heij

❮ Previous
Next ❯

Citations

Dec 17, 2015·Pediatric Surgery International·Marijke E B KremerL W Ernest van Heurn
Jun 15, 2017·British Journal of Neurosurgery·Francesca ColomboNeil Buxton
Feb 12, 2019·Pediatric Blood & Cancer·Julien RodSabine Sarnacki
Jul 1, 2019·Pediatric Surgery International·Lindel DewberryAndrea Bischoff
Nov 20, 2019·The Indian Journal of Radiology & Imaging·Shohei ChataniYoshitaka Inaba
Jul 12, 2019·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Yecai HuangJinyi Lang
Mar 3, 2021·American Journal of Medical Genetics. Part a·Aaron T ScottJames R Howe
Apr 11, 2021·Orphanet Journal of Rare Diseases·Gabriel C DworschakMichael Ludwig
Sep 1, 2021·Pediatric Surgery International·Tsuyoshi SakuraiNaobumi Endo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Radovi Medicinskog faculteta u Zagrebu
I Bradić, Z Pavelić
© 2022 Meta ULC. All rights reserved