Malignant transformation of endometriosis: application of laser microdissection for analysis of genetic alterations according to pathological changes

Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan
Akihiko SekizawaTetsuhiko Tachikawa

Abstract

Endometriosis is considered to be a possible precancerous disease. Pathologically, we observed malignant transformation of endometriosis to clear cell carcinoma or endometriotic carcinoma of the ovary, via the step of atypical endometriosis. Pathological changes reflected genetic alterations. In cases of clear cell carcinoma, we assessed K- ras mutations in regions of normal endometriosis, atypical endometriosis, and clear cell carcinoma, and obtained tissue samples by laser microdissection. We found that K- ras mutations were associated with malignant transformation of clear cell carcinoma. The present results indicate that laser microdissection can be used to combine assessment of genetic and pathological changes.

Citations

Sep 11, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ruriko YamadaTakao Fukaya
Aug 4, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T YagyuH Kobayashi
Dec 18, 2008·Zhonghua fu chan ke za zhi·Dong-Hui GuoYan Shen
Jan 16, 2007·American Journal of Reproductive Immunology : AJRI·Rui ChenGil Mor
Aug 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S AmemiyaT Okai
May 4, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K FujiwaraT Nishikawa
Jun 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Tomoko AkahaneTakashi Okai
Jun 22, 2018·Frontiers in Immunology·Tongwen OuWei Jiang

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