Malignant transformation of irradiated craniopharyngioma in children: report of 2 cases

Journal of Neurosurgery. Pediatrics
Kristian AquilinaFrederick A Boop

Abstract

Malignant transformation of craniopharyngioma is a rare event; only 3 cases have been reported in children, all in the Japanese literature. The authors describe 2 additional pediatric cases. Treatment in both of these cases consisted of multiple resections and external beam radiation therapy (EBRT). Malignant transformation occurred 7 and 8 years after EBRT. The authors also review another 6 cases in adults. A possible causative association with radiation therapy is discussed. As radiation is currently an important option in the management of craniopharyngiomas, this association requires further study.

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Citations

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Methods Mentioned

BETA
biopsy

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