Malignant transformation of mammalian cells initiated by constitutive expression of the polo-like kinase

Biochemical and Biophysical Research Communications
M R SmithD K Ferris

Abstract

Polo-like kinase (Plk) is the mammalian homologue of the Drosophila polo and Saccharomyces cerevisiae CDC5 genes, which are thought to be involved in regulating chromosomal segregation. Previously, we showed that transient ectopic expression of Plk could induce DNA synthesis in quiescent NIH 3T3 cells, suggesting that Plk might also have a function during G1 or S phase. Here we report that microinjection of Plk mRNA is sufficient to drive quiescent cells into mitosis and that constitutive expression of Plk in NIH 3T3 cells causes oncogenic focus formation. These transformed cells grow in soft agar and form tumors in nude mice. Because Plk expression has been shown to be high in various human tumors, we suggest that Plk may contribute to the promotion and/or progression of human cancers.

Citations

Jan 29, 2010·Pharmaceutical Research·Travis L SchmitNihal Ahmad
Jun 3, 2004·Nature Reviews. Molecular Cell Biology·Francis A BarrErich A Nigg
Sep 6, 2011·The Journal of Biological Chemistry·X Shawn LiuXiaoqi Liu
Jun 12, 2002·Molecular Biology of the Cell·Michael L WhitfieldDavid Botstein
Nov 4, 2005·Molecular Biology of the Cell·Anja HanischHerman H W Silljé
Sep 2, 2006·Nucleic Acids Research·Sven KappelKlaus Strebhardt
Jan 27, 2010·Nucleic Acids Research·Zdenek AndrysikEl Mustapha Bahassi
Feb 27, 2008·Acta Pharmacologica Sinica·Lin LiuPing Zou
Feb 4, 2009·Molecular and Cellular Biology·Thierry J HornerPerry J Blackshear
Mar 2, 2006·Molecular and Cellular Biology·Xiaoqi LiuRaymond L Erikson
Aug 2, 2012·Biochemistry Research International·Geun-Hyoung Ha, Eun-Kyoung Yim Breuer
Jan 24, 2009·Cell Division·Lin-Yu Lu, Xiaochun Yu
Jan 16, 2009·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hiroshi HiraiHidehito Kotani
Jun 1, 2012·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ding-pei HanAi-guo Lu
Sep 3, 2009·World Journal of Gastroenterology : WJG·Zi-Li HeDe-Wu Zhong
May 7, 2011·World Journal of Gastroenterology : WJG·Martyn Dibb, Yeng S Ang
Dec 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan J LiSara Antonia Li
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xiaoqi Liu, Raymond L Erikson
Apr 2, 2008·Current Oncology Reports·Steven L WarnerDaniel D Von Hoff
Nov 15, 2011·Clinical and Experimental Medicine·Julia A PezukLuiz G Tone
Jan 16, 1999·Current Opinion in Biotechnology·S A Courtneidge, G D Plowman
Jun 19, 2013·Chromosoma·Anna-Leena Salmela, Marko J Kallio
Dec 29, 2004·Leukemia & Lymphoma·Katsuhiko MitoShigeo Yokoyama
Oct 19, 2007·Leukemia & Lymphoma·Lin LiuPing Zou
Dec 16, 1998·The Journal of Cell Biology·J BählerD McCollum
Oct 17, 2006·Expert Opinion on Investigational Drugs·Mark R Miglarese, Robert O Carlson
Dec 17, 2009·Expert Opinion on Investigational Drugs·Puneet ChopraAbhijit Ray
Jul 14, 2009·Journal of Drug Targeting·Isabel SteinhauserBirgit Spänkuch
Dec 3, 2015·Investigational New Drugs·Hiroshi NokiharaTomohide Tamura
Jun 10, 2011·The Journal of Investigative Dermatology·Ahmad JaliliStephan N Wagner
Apr 24, 2003·Cancer Science·Takao TakahashiShigetoyo Saji
Sep 18, 2015·Frontiers in Oncology·Brian GeierPeter J Houghton
Feb 2, 2011·Pharmaceutical Biology·David E WilliamsRaymond J Andersen

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