Malignant transformation of renal angiomyolipoma: a case report

The American Journal of Surgical Pathology
Ken-ichi KawaguchiMasazumi Tsuneyoshi

Abstract

We report a case of renal angiomyolipoma (AML) with malignant transformation. A 28-year-old woman developed large bilateral renal masses 5 months before admission to our hospital. She was diagnosed with tuberous sclerosis when she was 4 years old. Total nephrectomy of the left kidney was performed, but she died during the operation. Although the focal region of the resected tumor had the appearance of a classic AML, most of the lesion showed a diffuse proliferation of atypical epithelioid cells resembling that in renal cell carcinoma. The epithelioid cells had extremely pleomorphic and hyperchromatic nuclei with frequent mitotic figures, including atypical forms. Immunohistochemical analysis revealed that the atypical epithelioid cells and the typical AML lesions were both positive for HMB-45 but that the former were negative for epithelial and myogenic markers. The smooth muscle cells and thick-walled vessels were focally positive for muscle-specific actins. Furthermore, the atypical epithelioid cells were immunoreactive for p53, whereas the foci of the typical AML were negative. Examination of the microdissected paraffin-embedded tissues revealed p53 mutations in the malignant epithelioid areas in AML but not in the renal par...Continue Reading

References

May 1, 1992·The Journal of Urology·B A LoweT Pitre
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N R RodriguesD P Lane
Nov 1, 1991·The American Journal of Surgical Pathology·J A FerryR H Young
Jun 6, 1991·Nature·A J LevineC A Finlay
Jan 1, 1985·The Journal of Urology·P J Kragel, C Toker
May 15, 1993·Cancer·R AshfaqJ Albores-Saavedra
Mar 1, 1996·Histopathology·K T MaiJ P Collins
May 20, 1999·The Journal of Urology·A P ChristianoG S Gerber
Sep 9, 1999·The American Journal of Surgical Pathology·H L'HostisJ M Coindre
Dec 22, 1999·Pathology, Research and Practice·C RöckenA Roessner

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Citations

Nov 3, 2009·Surgery Today·Koichi OishiToshihiro Nishida
Feb 27, 2004·Pediatric Neurology·Alberto LazarowskiAna Lía Taratuto
Jun 5, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Angel Panizo-SantosFrancisco J Pardo
Jan 10, 2006·Pathology International·Hidetaka YamamotoMasazumi Tsuneyoshi
Jan 30, 2004·Journal of Clinical Pathology·M SaitoK Nagashima
Feb 10, 2009·Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology·Tomoyuki KanekoYukio Homma
Nov 26, 2009·The British Journal of Radiology·N BharwaniS A Sohaib
Oct 10, 2012·World Journal of Surgical Oncology·Jun LiYan-Li Wang
Mar 1, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Mustafa Fuat AcikalinTurgut Dönmez
Apr 7, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Mar 1, 2011·The Kaohsiung Journal of Medical Sciences·Deyi LuoQiang Dong
Nov 1, 2016·Current Opinion in Urology·Barrett McCormickPhilippe E Spiess
Feb 6, 2017·Cancer Cytopathology·Haijun ZhouYun Gong
Jul 12, 2011·International Journal of Surgical Pathology·Qing-hua CaoZhi Li
Mar 31, 2012·International Journal of Surgical Pathology·Zhanyong BingPaul J Zhang
Nov 3, 2020·Pathology·Anna CaliòGuido Martignoni
Dec 10, 2020·Clinical Sarcoma Research·María Del Mar Galera LópezRosa Álvarez Álvarez
Feb 3, 2021·Mayo Clinic Proceedings·Sounak GuptaJohn C Cheville
Jan 16, 2010·Archives of Pathology & Laboratory Medicine·Guido MartignoniFranco Bonetti
Sep 25, 2004·Archives of Pathology & Laboratory Medicine·Khaldoon Aljerian, Andrew J Evans
Apr 30, 2011·Archives of Pathology & Laboratory Medicine·Ozgur Mete, Theodorus H van der Kwast
Apr 26, 2005·Clinics in Laboratory Medicine·Gregory T MacLennan, David G Bostwick
Oct 14, 2004·Annales de pathologie·Virginie AudardAnnick Vieillefond
Sep 6, 2005·Annales de pathologie·Eacute Va CompératAnnick Vieillefond
Aug 30, 2008·Pathology, Research and Practice·Yue-Feng DengXin-Fang Chen
May 12, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Kuo-How HuangJun Chen

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