Malignant transformation within a dermoid cyst: a case report and literature review

Archives of Gynecology and Obstetrics
P SangheraJ Simon

Abstract

Malignant transformation within a dermoid cyst is a rare event. The most common transformation is to squamous cell carcinoma. Patients are often elderly and present with advanced disease. The prognosis tends to be very poor. We present a case of locally invasive squamous cell carcinoma arising from a dermoid cyst in a 48-year-old lady. She underwent debulking surgery with no gross residual disease remaining. Within 2 months of the surgery she had recurrent disease and this was resistant to single agent carboplatin chemotherapy. She died 4 months after her initial surgery. We discuss the difficulties in diagnosing such tumours, the poor prognosis and review the various adjuvant treatment strategies that have been used in attempt to improve the outcome.

References

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Dec 12, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·V T DoG A Bjarnason
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Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TangjitgamolS Jesadapatarakul

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Citations

May 2, 2008·Archives of Gynecology and Obstetrics·Fatma Bahar CebesoyNecdet Aybasti
Feb 21, 2014·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Ankur BhatnagarPankaj Kumar Patel
Jul 2, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Renu MisraSuneeta Mittal
Mar 20, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Jonathan D BlackElena Ratner
Nov 12, 2016·Craniomaxillofacial Trauma & Reconstruction·Pablo BerbelFranco Tosti

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