Malignant transformation within ovarian dermoid cysts: an audit of treatment received and patient outcomes. an Australia New Zealand gynaecological oncology group (ANZGOG) and gynaecologic cancer intergroup (GCIG) study

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
M Corona GainfordMichael Friedlander

Abstract

Malignant transformation in an ovarian dermoid cyst occurs in 1% to 2% of cases. Our knowledge about this tumor type is limited and largely based on case reports. We aimed to collate and analyze the cumulative experience of how these patients have been managed in an effort to identify the most appropriate treatment strategies. A survey was sent to the members of the Gynaecologic Cancer Intergroup. Data collected included age, symptoms, stage, extent of surgery, chemotherapy and radiotherapy details, response to treatment, progression, survival, and salvage therapy. Data on 33 patients whose conditions were diagnosed between 1979 and 2007 were received from 10 centers in Australia, Canada, Germany, and Austria. The mean age was 49 years. All 15 patients with stage I disease and most of the patients with stages II and III were optimally debulked. Four patients with stage I disease had fertility-sparing surgery with good outcomes. Chemotherapy was not routinely given after surgery and did not seem to be effective. Platinum-based regimens were most commonly used. At relapse, 2 patients had a sustained remission after secondary surgery for relapsed disease. Second-line chemotherapy and radiotherapy were infrequently prescribed. Pati...Continue Reading

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Citations

Apr 4, 2017·The Journal of Obstetrics and Gynaecology Research·Yoshiko NankiDaisuke Aoki
Mar 25, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·An-Jen ChiangNelson N H Teng
Jul 30, 2020·Journal of Nematology·Iveth Del Rocio Castro-OrtegaVíctor Manuel Hernández-Velázquez
Nov 15, 2011·Diagnostic Cytopathology·David W Mensi
Feb 8, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jorge Rodriguez-PurataBuenaventura Coroleu

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