Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies

Journal of Neurology
Chloe BostJerome Honnorat

Abstract

The aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor. Retrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors. Sixty patients (23.8%) had an associated tumor and 15 (6%) were malignant. No particular neurological symptom was observed in these patients. Ovarian teratomas were the most frequent (51 cases) with 6 of them immature (11.8% of teratomas). Nine patients (3.6%) developed other malignant tumors (3 small cell lung carcinomas, 1 uterine adenocarcinoma, 1 prostate adenocarcinoma, 1 Hodgkin lymphoma, 1 pineal dysgerminoma, 1 neuroblastoma and 1 pancreatic neuroendocrine tumor). Among patients with a cancer other than teratoma, 6/9 were elderly patients (median age 65 years, representing 30% of elderly patients with such encephalitis) compared to a median age of 26 years in adult patients included herein. The clinical course was similar in the three groups, other than a higher death rate amo...Continue Reading

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Citations

Mar 15, 2019·Nature Reviews. Clinical Oncology·Francesc Graus, Josep Dalmau
Jun 23, 2020·Journal of Korean Medical Science·Chae Hyeong LeeJu Won Roh
Mar 13, 2019·Acta Neuropathologica Communications·Aude ChefdevilleVirginie Desestret
Mar 5, 2020·Auto- Immunity Highlights·Sergio Muñiz-CastrilloJérôme Honnorat
Apr 10, 2019·Case Reports in Immunology·Claudia Geraldine RitaÁngela Carrasco Sayalero
Jun 20, 2020·Archives of Gynecology and Obstetrics·Romain DelangleHenri Azaïs
Oct 28, 2019·Journal of Pediatric Hematology/oncology·Stefanie R Lowas, Christina K Lettieri
Nov 20, 2020·Open Forum Infectious Diseases·Karol PerlejewskiTomasz Laskus
May 20, 2021·Neurology. Neuroimmunology and Neuroinflammation·Francesc GrausJerome Honnorat
Jul 18, 2021·Current Problems in Pediatric and Adolescent Health Care·Ajay GoenkaGogi Kumar
Sep 24, 2019·Case Reports in Neurology·Lies Blomme, Kirsten Van de Velde
Jan 30, 2022·Autoimmunity Reviews·Nabil SeeryMastura Monif

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