Abstract
The aim of this study was to describe specificities of patients with NMDA receptor antibody (NMDAR-Ab) encephalitis associated with a malignant tumor. Retrospective observational study of 252 patients with NMDAR-Ab encephalitis of the French Paraneoplastic Neurological Syndrome Reference Center. Patients were classified in three groups: (1) non-malignant ovarian teratomas, (2) malignant ovarian teratomas (immature), and (3) other malignant tumors. Sixty patients (23.8%) had an associated tumor and 15 (6%) were malignant. No particular neurological symptom was observed in these patients. Ovarian teratomas were the most frequent (51 cases) with 6 of them immature (11.8% of teratomas). Nine patients (3.6%) developed other malignant tumors (3 small cell lung carcinomas, 1 uterine adenocarcinoma, 1 prostate adenocarcinoma, 1 Hodgkin lymphoma, 1 pineal dysgerminoma, 1 neuroblastoma and 1 pancreatic neuroendocrine tumor). Among patients with a cancer other than teratoma, 6/9 were elderly patients (median age 65 years, representing 30% of elderly patients with such encephalitis) compared to a median age of 26 years in adult patients included herein. The clinical course was similar in the three groups, other than a higher death rate amo...Continue Reading
References
Mar 22, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·E K OutwaterJ L Hunt
Jul 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·F GrausR Voltz
Sep 24, 2005·Annals of Neurology·Roberta VitalianiJosep Dalmau
Jan 31, 2007·Annals of Neurology·Josep DalmauDavid R Lynch
Oct 15, 2008·Lancet Neurology·Josep DalmauDavid R Lynch
Aug 15, 2009·Acta Neuropathologica·Erdem TüzünJosep Dalmau
Oct 17, 2009·Journal of Child Neurology·Axel LebasMarc Tardieu
Dec 10, 2009·Neurology·M S ZandiA Vincent
Dec 18, 2010·Lancet Neurology·Josep DalmauRita Balice-Gordon
Feb 4, 2011·Journal of Neurology·Makoto HaraJosep Dalmau
Jul 27, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Marcus DabnerColin J R Stewart
Jan 8, 2013·Lancet Neurology·Maarten J TitulaerJosep Dalmau
Dec 24, 2013·Lancet Neurology·Nuria Gresa-ArribasJosep Dalmau
Jan 21, 2014·Neurology·Aurélien ViaccozJérôme Honnorat
Apr 29, 2014·Geburtshilfe und Frauenheilkunde·U WagnerC Eggert
May 14, 2014·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Akram M ShaabanChristine O Menias
May 16, 2014·Journal of Clinical Neurology·Jung-Ah LimKon Chu
Jan 30, 2015·Pediatric Blood & Cancer·Monica TerenzianiGiovanni Cecchetto
May 20, 2015·Journal of Neurology·Anastasia ZekeridouJerome Honnorat
Oct 30, 2016·Tumori·Arzu ÇobanHakan Gürvit
Feb 26, 2016·Lancet Neurology·Francesc GrausJosep Dalmau
Mar 30, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M JeraibyS Paul
Mar 31, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ying-Ying WuJie-Wen Zhang
Jun 9, 2016·JAMA Neurology·Tanya J WilliamsEllen M Mowry
Jun 10, 2016·Neurology·Vadim AfanasievDimitri Psimaras
Feb 6, 2017·The Journal of Obstetrics and Gynaecology Research·Yukio HattoriNoriyuki Matsukawa
Mar 7, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ee Wei Lim, Chun Wai Yip
Jul 8, 2017·BMC Anesthesiology·Lei DingXuejun Song
Citations
Mar 15, 2019·Nature Reviews. Clinical Oncology·Francesc Graus, Josep Dalmau
Sep 26, 2019·Frontiers in Immunology·Robb WesselinghMastura Monif
Jun 23, 2020·Journal of Korean Medical Science·Chae Hyeong LeeJu Won Roh
Mar 13, 2019·Acta Neuropathologica Communications·Aude ChefdevilleVirginie Desestret
Mar 5, 2020·Auto- Immunity Highlights·Sergio Muñiz-CastrilloJérôme Honnorat
Apr 10, 2019·Case Reports in Immunology·Claudia Geraldine RitaÁngela Carrasco Sayalero
Jun 20, 2020·Archives of Gynecology and Obstetrics·Romain DelangleHenri Azaïs
Oct 28, 2019·Journal of Pediatric Hematology/oncology·Stefanie R Lowas, Christina K Lettieri
Nov 20, 2020·Open Forum Infectious Diseases·Karol PerlejewskiTomasz Laskus
May 20, 2021·Neurology. Neuroimmunology and Neuroinflammation·Francesc GrausJerome Honnorat
May 30, 2021·Journal of Neuroimmunology·Arka Prava ChakrabortySouvik Dubey
Jun 8, 2021·Disease Markers·Huiyun JiangXiaomao Li
Jul 18, 2021·Current Problems in Pediatric and Adolescent Health Care·Ajay GoenkaGogi Kumar
Sep 24, 2019·Case Reports in Neurology·Lies Blomme, Kirsten Van de Velde
Jan 30, 2022·Autoimmunity Reviews·Nabil SeeryMastura Monif