PMID: 9422323Jan 9, 1998Paper

Malignant tumors in the rectum simulating solitary rectal ulcer syndrome in endoscopic biopsy specimens

The American Journal of Surgical Pathology
S C Li, S R Hamilton

Abstract

Patients with solitary rectal ulcer syndrome (SRUS) frequently present with a mass that can be misinterpreted as cancer. In contrast, the occurrence and characteristics of SRUS-like histopathology produced by underlying malignancy have not been reported in detail. We report seven patients whose rectal mass that was induced by infiltrating carcinoma showed only histopathologic changes of SRUS on initial mucosal biopsy specimens. Carcinoma was evident in subsequent specimens after one to five repeat biopsies with delay in diagnosis from 1 week to 18 months in six patients. In one patient, infiltrating carcinoma was suggested on the first biopsy specimen by immunohistochemistry for cytokeratin. Three of the patients had primary rectal adenocarcinoma, two had metastatic carcinoma from stomach or ovary, and two had direct invasion of anal squamous cell carcinoma or prostatic adenocarcinoma. We conclude that the histopathology of SRUS may occasionally represent a characteristic but nonspecific mucosal reactive change to a deeper seated malignancy. The terminology "solitary rectal ulcer syndrome/mucosal prolapse changes" with a cautionary note may be useful for reporting biopsy results to emphasize the possibility of underlying primar...Continue Reading

References

Dec 1, 1992·Diseases of the Colon and Rectum·G A PeterkinE S Kondi
Mar 1, 1992·Diseases of the Colon and Rectum·J J TjandraJ W Milsom
Sep 1, 1991·The American Journal of Surgical Pathology·J K Kelly
Apr 1, 1988·Acta Pathologica Japonica·H Yamagiwa
May 1, 1987·Diseases of the Colon and Rectum·E BrittoL J DeSouza
Jun 1, 1985·The American Journal of Surgical Pathology·S H Saul, L C Sollenberger
Feb 1, 1966·American Journal of Clinical Pathology·S E EpsteinR Lattes
Sep 1, 1971·The British Journal of Surgery·A Talerman
Nov 1, 1969·Gut·M R Madigan, B C Morson
Nov 1, 1983·Journal of Clinical Pathology·C E du BoulayP G Isaacson
Mar 1, 1984·Diseases of the Colon and Rectum·M Stuart
Sep 1, 1980·AJR. American Journal of Roentgenology·P J FeczkoP H Frank
Oct 1, 1981·The British Journal of Surgery·C J MartinJ D Biggart
Mar 20, 1980·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·T Talseth
Oct 1, 1980·Diseases of the Colon and Rectum·J K MartinL H Weiland
Jan 1, 1981·The British Journal of Surgery·G ThomsonG Gillespie
Jan 1, 1995·International Journal of Colorectal Disease·Y S KangR J Nicholls
Nov 1, 1994·Journal of the Royal Society of Medicine·M Mercer-JonesM J Hershman
Jun 1, 1994·Yonsei Medical Journal·H J ParkC I Park
May 1, 1994·Radiology·K HizawaM Fujishima
Feb 1, 1993·Diseases of the Colon and Rectum·J J TjandraJ M Church

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Citations

Sep 2, 2006·Abdominal Imaging·Nagihan InanMelih Tugay
Sep 1, 2005·International Journal of Colorectal Disease·Jy-Ming ChiangJim-Ray Chen
Nov 10, 2007·Current Gastroenterology Reports·Anil B Nagar
Nov 2, 2011·Internal Medicine·Takashi NonakaYoshikiyo Akasaka
Jul 29, 2009·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Nabeel Al-BrahimMahmoud Ahmad
Dec 5, 2006·European Journal of Internal Medicine·Ignacio SztarkierJorge Delgado
Jan 24, 2006·Gastrointestinal Endoscopy·Norimitsu UzaTsutomu Chiba
Oct 26, 2005·Gastrointestinal Endoscopy·Ala I ShararaMohamad A Eloubeidi
May 28, 2010·International Journal of Surgical Pathology·Elizabeth Montgomery
May 11, 1999·The American Journal of Gastroenterology·K E Mönkemüller
Feb 22, 2005·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D J Tweedie, J S Varma
Dec 21, 2019·Annals of the Royal College of Surgeons of England·J D Coyne, P O'Byrne
Nov 30, 2019·ANZ Journal of Surgery·Kosuke OzakiSoichiro Ishihara
Jan 23, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Xuelian TangXiaohua Hou
Mar 10, 2001·Archives of Physical Medicine and Rehabilitation·F WangM A Klein
Sep 1, 2007·Photodiagnosis and Photodynamic Therapy·Wojciech LatosAleksander Sieroń

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