Malignant tumors of the sinonasal tract in the pediatric population

Acta Oto-laryngologica
Jong Sook YiBong-Jae Lee

Abstract

Sarcoma and lymphoma comprised 75% of 20 cases of pediatric sinonasal malignancies. As regards treatment, all 20 patients received chemotherapy and 6 patients (30%) underwent surgery. The overall 5-year survival rate was 52%, with favorable outcome for solid tumors compared with lymphoma. We aimed to investigate the clinical features and treatment outcomes of sinonasal malignancies in 20 pediatric patients. Clinical features were evaluated and tumors were staged according to the staging system for each histologic type. The 20 patients consisted of 12 males and 8 females, ranging in age from 1 to 16 years, with a median age of 9.6 years at diagnosis. More than half of the patients presented with nasal obstruction as the primary symptom, and mean symptom duration to diagnosis was 5.4 months. Primary tumor sites included the paranasal sinuses alone in four patients, the nasal cavity alone in eight, and both in eight. Eight tumors were sarcomas and seven were lymphomas. The remaining tumors included three olfactory neuroblastomas and two primitive neuroectodermal tumors. The main treatment modality was chemotherapy rather than surgery. The overall survival rate was 52%, and patients with solid tumors survived significantly longer t...Continue Reading

References

Aug 1, 1992·The Laryngoscope·P Dulguerov, T Calcaterra
Nov 1, 1993·Radiographics : a Review Publication of the Radiological Society of North America, Inc·D FiliatraultP Brochu
Jul 12, 2002·Oral Oncology·J Hicks, C Flaitz
Sep 11, 2002·Archives of Otolaryngology--head & Neck Surgery·Neil Bhattacharyya
Apr 20, 2004·International Journal of Radiation Oncology, Biology, Physics·Angel I BlancoCarlos A Perez
Dec 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·José L BlanchManuel Bernal-Sprekelsen
Jun 1, 2005·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Hans Theodor EichBarbara Hero
Jul 19, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jochen WurmHeinrich Iro
Dec 19, 2007·Pediatrics·Margo McKenna BenoitMichael Cunningham
Jun 10, 2008·British Journal of Haematology·Alfred Reiter, Wolfram Klapper
Apr 28, 2009·The Journal of Laryngology and Otology·G FyrmpasJ Constantinidis
Sep 2, 2009·International Journal of Pediatric Otorhinolaryngology·Nina L Shapiro, Neil Bhattacharyya
Oct 2, 2009·Oral and Maxillofacial Surgery·Bijan KhademiMohammad Mohammadianpanah
May 19, 2010·Journal of Cancer Research and Therapeutics·Olaf ZagolskiRehan Kazi

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Citations

May 6, 2014·The Journal of Surgical Research·David J GerthSeth R Thaller
Apr 24, 2015·Radiology·Daniel Thomas Ginat, Gul Moonis

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