PMID: 6166516May 1, 1981Paper

Mallory bodies in alcoholic and non-alcoholic liver disease contain a common antigenic determinant

Gut
K A FlemingJ O McGee

Abstract

An immunohistochemical technique is described for the detection of Mallory bodies (MBs) in paraffin sections of liver tissue. This is based on proteolytic digestion of sections before exposure to an antiserum which recognises a unique antigenic determinant in MBs. With the use of this procedure it has been shown in alcoholic liver disease, primary biliary cirrhosis. Indian childhood cirrhosis, Wilson's disease, diabetes mellitus, and hepatocellular cancer that the MBs found in these disorders contain this unique antigenic determinant. It is postulated, therefore, that the mechanism of formation of MBs is similar in liver diseases of diverse aetiology. In addition, it has been demonstrated that the immunohistochemical procedure is more sensitive than routine staining; MBs were detected in five out of 12 fatty livers by immunohistochemical and only in one by H and E staining. As MBs in fatty livers were not associated with polymorph filtration or fibrogenesis it is argued that MB formation is not an absolute prerequisite for the progression of acute to chronic liver disease.

References

Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W W FrankeK Weber
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H DenkD Kerjaschki

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Citations

Jul 1, 1984·Journal of Clinical Pathology·K A Fleming, J O McGee
Oct 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Jensen, C Gluud
Oct 1, 1986·Alcoholism, Clinical and Experimental Research·R D Johnson, R Williams
May 29, 2020·Nature Reviews. Gastroenterology & Hepatology·Herbert Tilg, Maria Effenberger
Sep 24, 2015·Journal of Food Science and Technology·I Prince DevadasonT R K Murthy
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·V J Desmet
Jan 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section A, Pathology·C GluudJ O McGee
May 28, 2021·World Journal of Gastroenterology : WJG·Lukas HartlLukas W Unger

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