Mallotojaponins B and C: Total Synthesis, Antiparasitic Evaluation, and Preliminary SAR Studies

Organic Letters
Tatyana D GrayferKevin Cariou

Abstract

The first total syntheses of mallotojaponin B and C as well as several analogues have been achieved. Biological evaluation of the synthesized compounds against Plasmodium falciparum and Trypanosoma brucei have also been carried out.

References

May 1, 1985·Journal of Natural Products·M ArisawaS Koshimura
Jan 20, 2004·Organic & Biomolecular Chemistry·Eric J TisdaleEmmanuel A Theodorakis
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Eric J TisdaleEmmanuel A Theodorakis
Jan 26, 2007·Organic & Biomolecular Chemistry·Ayse BatovaEmmanuel A Theodorakis
Apr 30, 2008·The Journal of Organic Chemistry·Yong Rok LeeJung Hee Kim
May 6, 2008·Organic Letters·Alberto MinassiGiovanni Appendino
Nov 13, 2009·Organic & Biomolecular Chemistry·Oraphin ChantarasriwongEmmanuel A Theodorakis
Jul 14, 2010·European Journal of Medicinal Chemistry·P BasabeJ G Urones
Aug 2, 2013·Bioorganic & Medicinal Chemistry·Marion ThéveninJoëlle Dubois
Jul 31, 2014·The New England Journal of Medicine·Elizabeth A AshleyUNKNOWN Tracking Resistance to Artemisinin Collaboration (TRAC)
Oct 2, 2015·The Journal of Organic Chemistry·Kenneth K C HongNaresh Kumar

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Citations

May 27, 2016·Journal of Natural Products·Alexander L EatonDavid G I Kingston
May 2, 2018·Chemical & Pharmaceutical Bulletin·Yumin DaiL Harinantenaina Rakotondraibe
Apr 21, 2020·Journal of Enzyme Inhibition and Medicinal Chemistry·Xiaohan DaiGao Hongwei

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