PMID: 3751557Jul 1, 1986Paper

Malnutrition: a cause of elevated sweat chloride concentration

Acta paediatrica Scandinavica
R BeckH Levison

Abstract

In order to document the frequency and causes of elevated sweat chlorides we reviewed all sweat chloride determinations performed over a 2-year period. Seven hundred and thirty-five quantitative tests were performed. Three hundred and three positive or borderline results were obtained from 133 patients. Thirty-three of these patients did not have clinical evidence of CF. Fourteen of them (42%) suffered from malnutrition or growth stunting when tested. The remaining patients who were normally nourished, represented a very heterogeneous group with no unifying diagnosis. Initial sweat chlorides in 11/14 malnourished children were in the abnormal range (greater than 60 mmol/l). These tended to revert to normal coincident with improvement in nutritional status. Less remarkable elevations in sweat chloride levels were noted in the normally nourished patients, since almost 50% (9/19) were in the intermediate range (50-60 mmol/l). We conclude that malnutrition can be the cause of elevated sweat chlorides, which may lead to an erroneous diagnosis of cystic fibrosis. Clinicians should be aware of this association and adhere to strict criteria for the diagnosis of cystic fibrosis. Also, repeated sweat chloride determinations should be obt...Continue Reading

References

Feb 1, 1978·The American Journal of Digestive Diseases·S BankB Novis
Oct 27, 1978·JAMA : the Journal of the American Medical Association·B J RosensteinS W Brusilow
Feb 1, 1979·The Journal of Pediatrics·R RosenfeldR Chicoine
May 1, 1971·Clinical Pediatrics·J W Mace, J E Schanberger
Apr 1, 1981·The Journal of Pediatrics·H ShwachmanR K Neff
Oct 1, 1981·The Journal of Pediatrics·J D Lloyd-Still

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Citations

Aug 1, 1994·Archives of Disease in Childhood·M E RodriguesF J Penna
Jan 30, 1988·British Medical Journal·P S BaxterE Worthy
Sep 12, 2008·European Journal of Pediatrics·Sevgi PekcanNural Kiper
Jan 30, 1988·British Medical Journal·N A Simmons
May 27, 2008·Pediatric Pulmonology·Mehmet KoseUgur Ozcelik
Mar 1, 1997·The Proceedings of the Nutrition Society·C R Pennington
Sep 10, 2003·Journal of Pediatric Gastroenterology and Nutrition·Hakan YiğitSevin Altinkaynak
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·M CancianiG Mastella

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