Malnutrition during late pregnancy exacerbates high-fat-diet-induced metabolic dysfunction associated with lower sympathetic nerve tonus in adult rat offspring.

Nutritional Neuroscience
Renan de Oliveira VenciAnanda Malta

Abstract

Objectives: We aimed to assess the effects of a maternal protein-caloric restriction diet during late pregnancy on the metabolism of rat offspring fed a high-fat diet (HFD) during adulthood.Methods: During late pregnancy, rat dams received either a low-protein (4%; LP group) or normoprotein (23%; NP group) diet. After weaning, the offspring were fed a standard diet (Control; C). Male offspring (60 days old) from both groups were then fed either the C diet or HFD until they were 90 days old. The adult offspring and maternal metabolic parameters and autonomic nervous system (ANS) were then evaluated.Results: Dams exhibited low body weight gain and food intake during the LP diet consumption. At lactation, these dams showed high body weight gain, hypoinsulinemia and hyperglycemia. The maternal LP diet resulted in low body weights for the pups. There were also no differences in the metabolic parameters between the adult LP offspring that were fed the C diet and the NP group. Adults of both groups that were fed the HFD developed obesity associated with altered insulin/ glucose homeostasis and altered ANS activity; however, the magnitudes of these parameters were higher in the LP group than in the NP group.Conclusions: Maternal protei...Continue Reading

References

Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Jul 1, 1995·European Journal of Clinical Investigation·D J Barker
Mar 15, 1993·Annals of the New York Academy of Sciences·J TonkissR J Austin-LaFrance
Feb 12, 1998·Diabetologia·A GarofanoB Bréant
Oct 28, 1999·The American Journal of Clinical Nutrition·A C RavelliO P Bleker
Jan 29, 2000·The American Journal of Clinical Nutrition·A Lucas
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·Mark H VickersP D Gluckman
Mar 10, 2001·The Journal of Nutrition·R UauyJ Kain
Apr 3, 2002·The Journal of Endocrinology·Clarice GravenaStephen J H Ashcroft
Sep 10, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Giovanni Pacini, Andrea Mari
Jan 30, 2004·Nature·S E Ozanne, C N Hales
Jul 4, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Barry E Levin
Aug 3, 2006·Maternal & Child Nutrition·Simon C Langley-EvansSarah McMullen
Apr 3, 2007·The Journal of Endocrinology·Bettina A Ikenasio-ThorpeMhoyra Fraser
Apr 12, 2007·Obesity·Roland BuettnerL Cornelius Bollheimer
Apr 20, 2007·The British Journal of Nutrition·Aml ErhumaAndrew J Bennett
Aug 30, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Karen L Teff
Dec 20, 2008·Trends in Endocrinology and Metabolism : TEM·Beverly Muhlhausler, Steven R Smith
Aug 13, 2009·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A T S FagundesPatricia Cristina Lisboa
Nov 26, 2010·Journal of Neuroendocrinology·J C de OliveiraPaulo C F Mathias
Jun 30, 2011·American Journal of Physiology. Endocrinology and Metabolism·Marie-Amélie LukaszewskiChristophe Breton
Dec 14, 2011·Paediatric and Perinatal Epidemiology·Céline DruetKen K Ong
Mar 23, 2012·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Luiz Felipe BarellaPaulo Cezar de Freitas Mathias
Apr 28, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruijun HanZofia Zukowska
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Christian Rask-Madsen, C Ronald Kahn
Sep 13, 2012·Nutrition & Metabolism·Júlio Cezar de OliveiraPaulo Cezar Freitas de Mathias
Jul 25, 2013·Frontiers in Physiology·Jacqueline F O'Dowd, Claire J Stocker
Sep 3, 2013·Journal of Diabetes Research·Abdel-Baset M ArefMargit Semmler
Jun 11, 2014·Journal of the International Society of Sports Nutrition·Wilson RinaldiJúlio Cezar de Oliveira
Nov 16, 2014·Experimental Physiology·Luiz Felipe BarellaJúlio Cezar de Oliveira
Dec 5, 2014·PharmacoEconomics·Adela Hruby, Frank B Hu
Jul 3, 2015·European Journal of Nutrition·Ananda MaltaJúlio Cezar de Oliveira
Feb 3, 2016·Nihon eiseigaku zasshi. Japanese journal of hygiene·Fumihiro Sata

Citations

Jan 24, 2019·The British Journal of Nutrition·Rafael Oliveira PinheiroJailane de Souza Aquino
Dec 13, 2019·The Journal of Physiology·Carla Bruna PietrobonEgberto Gaspar de Moura
Sep 3, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emilyn U AlejandroErnesto Bernal-Mizrachi

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