Malnutrition in adults with cystic fibrosis

European Journal of Clinical Nutrition
Xavier DrayDominique Hubert

Abstract

To determine the prevalence and clinical features of malnutrition and its relationship with the CFTR genotype in a cystic fibrosis (CF) adult population. Cross-sectional study. Department of Pulmonology, Cochin Hospital, Paris, France. 163 CF adults seen between 1997 and 1999. Mean age was 28.8 y. Mean body mass index (BMI) was 19.1 kg/m2. Malnutrition (BMI<18.5 kg/m2) was seen in 81 patients (49.7%). Its severity was associated with diagnosis of CF before the age of 18 y (P<0.01), FEV1 values below 30% (P<0.01), the yearly decline of FEV1 (P<0.01), pancreatic insufficiency (P<0.01) and gastro-oesophageal reflux (P<0.01). Malnutrition was observed in 58.7% of patients with a severe CFTR genotype but in 28.6% of patients with a mild genotype (P<0.001). Malnutrition remains frequent in adults with CF except in patients presenting with a mild CFTR genotype (leading to a mild phenotype and to later diagnosis).

References

Apr 30, 1992·The New England Journal of Medicine·E KeremH Levison
Jun 1, 1995·The New England Journal of Medicine·M ChillónM Claustres
Jan 1, 1995·Annual Review of Genetics·J Zielenski, L C Tsui
Nov 1, 1996·The European Respiratory Journal·D HubertD J Dusser
Feb 13, 1997·The New England Journal of Medicine·R C Stern
Feb 11, 1998·Lancet·B J Rosenstein, P L Zeitlin
Jun 27, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M H Schöni, C Casaulta-Aebischer

❮ Previous
Next ❯

Citations

Aug 1, 2007·Archivos de bronconeumología·Casilda Olveira FusterFrancisco Miralles Lozano
Apr 28, 2009·Respiratory Care·Patrick A Flume
May 10, 2011·Revue des maladies respiratoires·J ChapronP-R Burgel
Oct 14, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Ingrid DuguépérouxDominique Hubert
Sep 6, 2013·Pediatrics International : Official Journal of the Japan Pediatric Society·Paraskevi PanagopoulouSanda Nousia-Arvanitakis
Sep 26, 2006·International Journal of Nursing Studies·Cathy Kubrak, Louise Jensen
Sep 18, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·F M HollanderJ A Iestra
Aug 3, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Arash A SabatiKhalid M Khan
Mar 22, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Esi Morgan DewittShelby D Reed
Apr 22, 2006·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Ingrid DuguépérouxIsabelle Durieu
Jul 8, 2011·Journal of the Royal Society of Medicine·Alexandra HigtonDiana Bilton
Jan 6, 2007·Journal of Pediatric Gastroenterology and Nutrition·Helen WhiteKeith B Brownlee
Aug 3, 2017·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Gabriela Cristofoli BarniPaulo de Tarso Roth Dalcin
Nov 28, 2020·World Journal of Gastroenterology : WJG·Annarita BongiovanniSalvatore Leonardi
Aug 4, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Ayse Ayzit KilincHaluk Cokugras

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
M SinaasappelG Döring
Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
S C BellJ S Elborn
Current Treatment Options in Gastroenterology
Maria R. Mascarenhas
Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Eitan KeremConsensus Committee
© 2021 Meta ULC. All rights reserved