Malnutrition: Modulator of Immune Responses in Tuberculosis

Frontiers in Immunology
Padmapriyadarsini ChandrasekaranSrikanth Tripathy

Abstract

Nutrition plays a major role in the management of both acute and chronic diseases, in terms of body's response to the pathogenic organism. An array of nutrients like macro- and micro-nutrients, vitamins, etc., are associated with boosting the host's immune responses against intracellular pathogens including mycobacterium tuberculosis (M.tb). These nutrients have an immunomodulatory effects in controlling the infection and inflammation process and nutritional deficiency of any form, i.e., malnutrition may lead to nutritionally acquired immunodeficiency syndrome, which greatly increases an individual's susceptibility to progression of infection to disease. This narrative review looks at the various mechanisms by which nutrition or its deficiency leads to impaired cell mediated and humoral immune responses, which in turn affects the ability of an individual to fight M.tb infection or disease. There is very little evidence in the literature that any specific food on its own or a specific quantity can alter the course of TB disease or be effective in the treatment of malnutrition. Further clinical trials or studies will be needed to recommend and to better understand the link between malnutrition, tuberculosis, and impaired immunity.

References

May 16, 2002·The Journal of Biological Chemistry·Sarah Spiegel, Sheldon Milstien
Jul 27, 2002·European Journal of Clinical Nutrition·W Savino
Jun 21, 2003·The American Journal of Clinical Nutrition·Tesfaye MadeboRolf K Berge
Jul 15, 2003·Clinical Microbiology Reviews·Issar Smith
Aug 20, 2003·The Journal of Experimental Medicine·Isabelle VergneVojo Deretic
Apr 9, 2005·Clinical and Diagnostic Laboratory Immunology·Leonor RodríguezRocío Ortiz
Sep 24, 2005·Infection and Immunity·S de VallièreD F Hoft
Oct 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiangyang DongMatthew D Griffin
Feb 28, 2007·Archives of Internal Medicine·Michael N BatesKirk R Smith
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul J MaglioneJohn Chan
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sheng ChenPeter E Lipsky
Aug 30, 2007·Annals of Nutrition & Metabolism·Eva S WintergerstDietrich H Hornig
Feb 5, 2008·International Journal of Epidemiology·Kelechi E Nnoaham, Aileen Clarke
Mar 15, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Ensiyeh SeyedrezazadehMasood Pourmogaddam
Aug 16, 2008·BMC Public Health·Knut LönnrothChristopher Dye
Dec 17, 2008·Mini Reviews in Medicinal Chemistry·E Anes, L Jordao
Apr 28, 2009·Social Science & Medicine·Knut LönnrothMario Raviglione
Oct 13, 2009·International Journal of Epidemiology·Knut LönnrothChristopher Dye
Jul 7, 2010·Cell·Matthias W HentzeClara Camaschella
Jul 30, 2011·Chemistry and Physics of Lipids·David N McMurrayRobert S Chapkin
Mar 12, 2013·Pulmonary Medicine·Padmanesan NarasimhanDilip Mathai
Nov 10, 2013·Journal of the American Society of Nephrology : JASN·Justine BacchettaMartin Hewison
Apr 9, 2014·Antimicrobial Agents and Chemotherapy·Kidola JeremiahAase Bengaard Andersen
Jun 11, 2014·Critical Reviews in Food Science and Nutrition·Surya KantSavita Ahluwalia
Dec 3, 2014·Seminars in Immunology·Marilena Paola EtnaEliana Marina Coccia
Feb 24, 2015·Immunological Reviews·Olivier NeyrollesMichael Niederweis
Mar 7, 2015·Canadian Journal of Physiology and Pharmacology·Paramasivam SelvarajKolloli Afsal
Mar 15, 2015·Tuberculosis·Peter A MinchellaJayne S Sutherland
Sep 25, 2015·The American Journal of Clinical Nutrition·Nestan TukvadzeThomas R Ziegler

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Citations

Jul 16, 2019·The Pediatric Infectious Disease Journal·Agnes GwelaChristina Lancioni
May 26, 2020·Expert Review of Anti-infective Therapy·George PrayGod
Jul 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Morgan MaioliniRahul R Deshmukh
Oct 12, 2018·Biology of Sex Differences·Wenling TanYonghong Feng
May 16, 2020·Frontiers in Cellular and Infection Microbiology·Anuradha RajamanickamSubash Babu
May 22, 2019·Pharmaceuticals·Rafiou Agoro, Catherine Mura
Nov 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tapan BehlSimona Bungau
Mar 2, 2021·The Indian Journal of Tuberculosis·Benhur Joel ShadrachRishabh Goel
May 1, 2021·Journal of Clinical Medicine·Patricia Comella-Del-BarrioJosé Domínguez

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