PMID: 9550350Jan 1, 1996Paper

Malondialdehyde serum concentration in type 1 diabetic with and without retinopathy

Documenta Ophthalmologica. Advances in Ophthalmology
M Losada, J L Alio

Abstract

Lipid peroxides are thought to be formed by free radicals and have been implicated in the pathogenesis of diabetes complications. A convenient and sensitive method for estimation of lipid peroxide concentration is the quantitative estimation of their metabolic end-product malondialdehyde (MDA) expressed in mmol/L using the thiobarbituric acid test (TBA-test). We have measured the serum concentrations of MDA in 60 well controlled type I diabetic patients (28 without retinopathy and 32 with retinopathy) and 13 age-matched healthy subjects. Patients with retinopathy showed significantly increased MDA level (2.65+/-1.00) compared to diabetics without retinopathy (1.80+/-0.81) and healthy controls (1.47+/-0.45). The serum levels of MDA correlated best with glycosylated haemoglobin (r=0.28), serum triglyceride concentration (r=0.29) and serum cholesterol concentration. (r=0.47). Increased lipid peroxides suggesting increased free radical activity is associated with retinopathy and this may have pathogenetic implications.

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Citations

Sep 1, 2010·Journal of Ocular Biology, Diseases, and Informatics·Sandeep SaxenaVinay K Khanna
Jun 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Alan W Stitt, Timothy M Curtis
Oct 25, 2001·European Journal of Pharmacology·M E SzaboR P Garay
Dec 16, 2000·Eye·B GürlerN Aksoy
Oct 14, 2008·European Journal of Ophthalmology·G BaskolS Karakucuk
Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Paul E Milbury
Jun 15, 2000·Journal of Endocrinological Investigation·S BüyükkoçakI Durak
Mar 9, 2021·Frontiers in Endocrinology·Josy AugustineTim M Curtis

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