Malonylation is a key reaction in the metabolism of xenobiotic phenolic glucosides in Arabidopsis and tobacco

The Plant Journal : for Cell and Molecular Biology
Goro TaguchiNobuaki Hayashida

Abstract

Tobacco cells (Nicotiana tabacum L.) accumulate harmful naphthols in the form of malonylated glucosides (Taguchi et al., 2005). Here, we showed that the malonylation of glucosides is a system to metabolize xenobiotics and is common to higher plants. Moreover, some plantlets including Arabidopsis thaliana excreted some of the incorporated naphthols into the culture media as their glucosides. In order to analyze the function of malonylation in the metabolism of these xenobiotics, we identified a malonyltransferase gene (At5g39050) responsible for the malonylation of these compounds in A. thaliana. The recombinant enzyme had malonyltransferase activity toward several phenolic glucosides including naphthol glucosides. A knockout mutant of At5g39050 (pmat1) exposed to naphthols accumulated only a few malonylglucosides in the cell, and released larger amounts of simple glucosides into the culture medium. In contrast, forced expression of At5g39050 in the pmat1 mutant resulted in increased malonylglucoside accumulation and decreased glucoside excretion to the media. The results provided clear evidence of whether the release of glucosides or the storage of malonylglucosides was determined by the At5g39050 expression level. A similar ev...Continue Reading

References

Oct 21, 1998·The Plant Journal : for Cell and Molecular Biology·M SekiK Shinozaki
Mar 9, 1999·The Plant Journal : for Cell and Molecular Biology·S J Clough, A F Bent
Mar 21, 2000·Archives of Physical Medicine and Rehabilitation·T AlbertJ P Lassau
May 16, 2000·Plant Science : an International Journal of Experimental Plant Biology·G TaguchiM Okazaki
Sep 7, 2000·Phytochemistry·K R MarkhamG K Rickards
Mar 23, 2002·Science·Motoaki SekiKazuo Shinozaki
Jun 1, 1996·Plant Physiology·K. KreuzE. Martinoia
Aug 2, 2003·Science·José M AlonsoJoseph R Ecker
Apr 13, 2005·The Journal of Biological Chemistry·Scott R BaersonStephen O Duke
Apr 30, 2005·The Plant Journal : for Cell and Molecular Biology·Melissa Brazier-Hicks, Robert Edwards
Apr 18, 2006·Current Opinion in Plant Biology·John C D'Auria
Oct 23, 2008·The Plant Journal : for Cell and Molecular Biology·Fumio MatsudaKazuki Saito
Mar 1, 1985·Journal of Plant Physiology·C Werner, P Matile

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Citations

Oct 12, 2012·Plant Molecular Biology·Hiroki UenoNobuaki Hayashida
May 7, 2013·Phytochemistry·Dmitry V KochkinAlexander M Nosov
Sep 10, 2015·Environmental Science & Technology·Abdelhak El AmraniRichard Berthomé
Jul 25, 2015·Trends in Plant Science·Jian Zhao
Nov 18, 2016·Scientific Reports·Nikolay VasilevStefan Schillberg
Nov 1, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ping-Ping WangAi-Xia Cheng
Nov 20, 2016·The Journal of Biological Chemistry·Bibi Rafeiza KhanElison B Blancaflor
Mar 15, 2019·Pest Management Science·Carla Díaz-TielasStephen O Duke
Dec 19, 2019·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Gabriel Soares Guerra, Andrea Balan
Dec 9, 2016·Toxins·Jacqueline Meng-ReitererRainer Schuhmacher
Aug 1, 2020·Frontiers in Plant Science·Armand Cavé-RadetAbdelhak El Amrani
Feb 14, 2021·Genomics, Proteomics & Bioinformatics·Ning ZhangFeng Chen
Feb 19, 2021·The Journal of Biological Chemistry·Sufu GanBrigitte Poppenberger
Apr 3, 2021·Cell·Noah K Whiteman, Rebecca L Tarnopol
May 5, 2021·Trends in Genetics : TIG·Louis-Valentin MéteignierVincent Courdavault
May 28, 2021·Journal of Agricultural and Food Chemistry·Keita MatsushimaTakuo Fujisawa
Jun 11, 2021·The Science of the Total Environment·Jing Jing Zhang, Hong Yang
Jun 22, 2021·Critical Reviews in Biotechnology·Linlin WangXue Qiao
Sep 13, 2018·Journal of Agricultural and Food Chemistry·Daisuke AndoToshiyuki Katagi
Mar 28, 2019·Environmental Science & Technology·Khang Huynh, Dawn Reinhold

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