Sep 25, 2008

MalVac: database of malarial vaccine candidates

Malaria Journal
Rupanjali ChaudhuriSrinivasan Ramachandran

Abstract

The sequencing of genomes of the Plasmodium species causing malaria, offers immense opportunities to aid in the development of new therapeutics and vaccine candidates through Bioinformatics tools and resources. The starting point of MalVac database is the collection of known vaccine candidates and a set of predicted vaccine candidates identified from the whole proteome sequences of Plasmodium species provided by PlasmoDb 5.4 release (31st October 2007). These predicted vaccine candidates are the adhesins and adhesin-like proteins from Plasmodium species, Plasmodium falciparum, Plasmodium vivax and Plasmodium yoelii. Subsequently, these protein sequences were analysed through 20 publicly available algorithms to obtain Orthologs, Paralogs, BetaWraps, TargetP, TMHMM, SignalP, CDDSearch, BLAST with Human Ref. Proteins, T-cell epitopes, B-cell epitopes, Discotopes, and allergen predictions. All of this information was collected and organized with the ORFids of the protein sequences as primary keys. This information is relevant from the view point of Reverse Vaccinology in facilitating decision making on the most probable choice for vaccine strategy. Detailed information on the patterning of the epitopes and other motifs of importanc...Continue Reading

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  • References32
  • Citations17

Citations

Mentioned in this Paper

Establishment and Maintenance of Localization
Adhesins, Bacterial
T-Lymphocyte
Molecular Helix
Genome
Phyllostachys vivax
Vaccines
Plasmodium yoelii
Plasmodium vivax
Helix (Snails)

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