MAML2 rearrangement in Warthin's tumour: a fluorescent in situ hybridisation study of metaplastic variants

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Matteo RotelliniAlessandro Franchi

Abstract

Warthin's tumour (WT) is a common benign lesion of the major salivary glands. The nature of WT remains controversial, with particular regard to the presence of clonal chromosomal abnormalities, including the t(11;19) translocation involving the CRTC1 and MAML2 genes, that have been identified in both WT and mucoepidermoid carcinoma. In this study, we focused our attention on metaplastic WT variants, and we conducted a fluorescent in situ hybridisation (FISH) analysis for the presence of MAML2 gene rearrangement. Dual-colour FISH analysis was performed on paraffin-embedded sections of eight WTs showing metaplastic changes (five with squamous metaplasia, two with mucinous metaplasia and one with both) using a MAML2 break-apart probe. Presence of split signals indicative of gene rearrangement was identified in a subset of cells in areas of squamous metaplasia in two samples of WT. No rearrangement was observed in the oncocytic epithelium, in lymphocytes and in areas of mucinous metaplasia. The presence of a small subpopulation of cells carrying MAML2 rearrangement in areas of squamous metaplasia within WT could predispose these lesions to malignant transformation in mucoepidermoid carcinoma and could represent a molecular link bet...Continue Reading

References

Mar 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·J W Eveson, R A Cawson
Oct 1, 1987·American Journal of Surgery·J LamelasA E Alfonso
May 1, 1982·The Annals of Otology, Rhinology, and Laryngology·J M ShugarH F Biller
Feb 1, 1995·Cancer Genetics and Cytogenetics·R DahlenforsJ Mark
Sep 1, 1994·Cancer Genetics and Cytogenetics·A NordkvistG Stenman
Feb 12, 1998·Oral Oncology·C MartinsJ Soares
Jun 10, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·K TakezawaT C King
Jul 6, 2000·The Journal of Pathology·P D LewisD O Skibinski
Nov 1, 1953·Cancer·F W FOOTE, E L FRAZELL
Oct 11, 2003·Molecular Cell·Michael D ConkrightMarc Montminy
Jul 23, 2004·The Journal of Molecular Diagnostics : JMD·Carmo MartinsIsabel Fonseca
Apr 30, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Muammar AridaJennifer L Hunt
May 25, 2005·Virchows Archiv : an International Journal of Pathology·A Teymoortash, J A Werner
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitsukuni OkabeHiroshi Inagaki
Jul 11, 2006·The Journal of Molecular Diagnostics : JMD·Marta WinnesGöran Stenman
Jan 22, 2008·Cancer Genetics and Cytogenetics·André FehrJörn Bullerdiek
Mar 26, 2008·Cancer·Siegal SadetzkiMichael Wolf
Jul 24, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Iain David O'Neill
Jul 1, 2010·The American Journal of Surgical Pathology·Raja R SeethalaMarina N Nikiforova

❮ Previous
Next ❯

Citations

Oct 13, 2015·The American Journal of Surgical Pathology·Kenichiro IshibashiHiroshi Inagaki
Jan 24, 2015·Seminars in Diagnostic Pathology·Marc P Pusztaszeri, William C Faquin
Jul 30, 2017·Diagnostic Cytopathology·Jen-Fan HangJustin A Bishop
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer L Hunt
Mar 31, 2020·Virchows Archiv : an International Journal of Pathology·Michał BieńkowskiWojciech Biernat

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Iain D O'Neill
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Lorena GallegoLucas Villalaín
© 2021 Meta ULC. All rights reserved