PMID: 9177577May 30, 1997Paper

Mammal toxicity assessment of the plant molluscicide, Apodytes dimidiata (Icacinaceae), in South Africa

Acta Tropica
T D BrackenburyG Thurman

Abstract

Apodytes dimidiata has recently come to the fore as a potential plant molluscicide for schistosomiasis control in rural communities in South Africa. Prior to field applications of its leaves and extract to waterbodies, selected acute and sub-acute mammal toxicity tests were conducted in accordance with the Organisation of Economic Cooperation and Development (OECD) Guidelines to identify any potential hazards that might arise form the plant's use. Acute and sub-acute mammal toxicity test results classified A. dimidiata as non-toxic and non-irritating. Based on this toxicity evaluation, the dried leaf material and aqueous extracts of this plant are considered safe for use in preliminary field trials.

References

Oct 1, 1991·Regulatory Toxicology and Pharmacology : RTP·J D LambertD de Savigny
Jan 1, 1982·Pharmacology & Therapeutics·P AndrewsD Lorke

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Citations

May 24, 2011·Phytochemistry·Kenn FoubertLuc Pieters
Jan 11, 2011·Travel Medicine and Infectious Disease·Jan Clerinx, Alfons Van Gompel

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