Mammalian cell transformation and cell-mediated mutagenesis by carcinogenic polycyclic hydrocarbons.

Mutation Research
E Huberman

Abstract

The introduction of a polycyclic hydrocarbon such as benzo(alpha)pyrene (BP) into normal golden hamster embryo cell cultures results, in addition to cytotoxicity, in malignant cell transformation. Studies on the effect of different doses of BP on the normal cells showed that the frequency of transformed colonies was directly related to the dose of the carcinogen. Analysis of this dose-response curve suggests a one-event ("one-hit") response for transformation by this carcinogen. The one-event response for transformation by carcinogenic polycyclic hydrocarbons and the fact that these carcinogens bind to DNA in susceptible cells suggests that transformation can involve a single alteration in the genetic constitution of the treated cells. Carcinogens may, therefore, produce somatic mutations, some of which may involve the genes that control malignancy. Recently, considerable progress has been made in developing models for the study of chemical mutagenesis in mammalian cells. Using resistance to 8-azaguanine as a marker, positive correlations between mutagenicity and transformation were obtained with chemically reactive carcinogens such as N-acetoxy-N-2-fluorenyl-acetamide, N-methyl-N'-nitro-N-nitrosoguanidine and K-region epoxides...Continue Reading

References

Jun 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·P L GroverC Heidelberger
Nov 1, 1967·Experimental Cell Research·J A Dipaolo, P J Donovan
Dec 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·H V GelboinL Sachs
Jun 20, 1973·Nature: New Biology·T YamamotoL Sachs
Mar 15, 1973·International Journal of Cancer. Journal International Du Cancer·E Huberman, L Sachs
Mar 15, 1974·International Journal of Cancer. Journal International Du Cancer·E Huberman, L Sachs
Mar 15, 1969·International Journal of Cancer. Journal International Du Cancer·T T Chen, C Heidelberger
Oct 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·E Huberman, L Sachs
Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·F T Kao, T T Puck
Dec 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·E H Chu, H V Malling
Jan 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S Mondal, C Heidelberger
Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·E HubermanP Sims

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Citations

Feb 1, 1986·Bulletin of Environmental Contamination and Toxicology·J H Vandermeulen, R W Lee
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W LevinA H Conney
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E HubermanV Gelboin
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H B GamperJ C Bartholomew
Jul 1, 1977·Journal of Toxicology and Environmental Health·E H ChuC C Chang
Jun 1, 1979·Environmental Health Perspectives·Y V Pashin, L M Bakhitova
Mar 1, 1980·American Journal of Public Health·N Gruener, M P Lockwood
Mar 14, 2021·Environmental Pollution·Francisco Carlos da Silva JuniorSilvia Regina Batistuzzo de Medeiros

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