Apr 7, 2020

Multimodal Nonlinear Optical and Thermal Imaging Platform for Label-Free Characterization of Biological Tissue

BioRxiv : the Preprint Server for Biology
W. R. AdamsAnita Mahadevan-Jansen

Abstract

The ability to characterize the combined structural, functional, and thermal properties of biophysically dynamic samples is needed to address critical questions related to tissue structure, physiological dynamics, and disease progression. Towards this, we have developed an imaging platform that enables multiple nonlinear imaging modalities to be combined with thermal imaging on a common sample. Here we demonstrate label-free multimodal imaging of live cells, excised tissues, and live rodent brain models. While potential applications of this technology are wide-ranging, we expect it to be especially useful in addressing biomedical research questions aimed at the biomolecular and biophysical properties of tissue and their physiology.

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Mentioned in this Paper

Vertebrates
Disorder of Middle Ear
Malignant Neoplasm of Middle Ear
Entire Middle Ear
Jaw
Mandible
Entire Malleus
Entire Tympanic Anulus
Ear Ossicle Structure
Right Middle Ear Structure

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