Mammalian lipin phosphatidic acid phosphatases in lipid synthesis and beyond: metabolic and inflammatory disorders.

Journal of Lipid Research
Karen Reue, Huan Wang

Abstract

The regulation of cellular lipid storage and membrane lipid composition plays a critical role in metabolic homeostasis, and dysregulation may contribute to disorders such as obesity, fatty liver, type 2 diabetes, and cardiovascular disease. The mammalian lipin proteins (lipin 1, lipin 2, and lipin 3) are phosphatidic acid phosphatase (PAP) enzymes that modulate levels of cellular triacylglycerols and phospholipids, and also regulate lipid intermediates in cellular signaling pathways. Lipin proteins also have the ability to coactivate/corepress transcription. In humans and mice, lipin gene mutations cause severe metabolic phenotypes including rhabdomyolysis (lipin 1), autoinflammatory disease (lipin 2), and impaired intestinal lipoprotein assembly (lipin 2/lipin 3). Characterization of these diseases has revealed roles for lipin PAP activity in fundamental cellular processes such as autophagy, inflammasome activation, and lipoprotein assembly. Lipin protein activity is regulated at pre- and posttranscriptional levels, which suggests a need for their ordered response to specific physiological stimuli. Challenges for the future include better elucidation of the unique biochemical and physiological properties of individual lipin fa...Continue Reading

References

Aug 2, 2005·Cell Metabolism·Jack Phan, Karen Reue
Feb 10, 2006·The Journal of Biological Chemistry·Gil-Soo HanGeorge M Carman
Nov 16, 2006·The Journal of Biological Chemistry·Thurl E HarrisJohn C Lawrence
Dec 13, 2006·The Journal of Biological Chemistry·Jimmy DonkorKaren Reue
Mar 3, 2007·Arthritis and Rheumatism·Zakiya S Al-MosawiPolly J Ferguson
Apr 15, 2008·Human Mutation·Florian MilhavetIsabelle Touitou
Aug 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhouji ChenBrian N Finck
Dec 4, 2009·The Journal of Biological Chemistry·Miklós PéterfyKaren Reue
Jun 29, 2010·Human Mutation·Caroline MichotPascale de Lonlay
Apr 8, 2011·Trends in Endocrinology and Metabolism : TEM·Thurl E Harris, Brian N Finck
Jun 2, 2011·Chemical Reviews·Rosalind A Coleman, Douglas G Mashek
Aug 6, 2011·Cell·Timothy R PetersonDavid M Sabatini
Oct 13, 2011·Biochimica Et Biophysica Acta·Xiaoyue Pan, M Mahmood Hussain
Apr 7, 2012·The Journal of Pediatrics·Jean BergouniouxPascale de Lonlay
Apr 7, 2012·Journal of Inherited Metabolic Disease·Caroline MichotPascale de Lonlay
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jennifer R DwyerKaren Reue
Oct 23, 2012·Annals of the Rheumatic Diseases·Troels HerlinPolly J Ferguson
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mayurranjan S MitraBrian N Finck
Apr 23, 2013·Progress in Lipid Research·Lauren S CsakiKaren Reue
Mar 19, 2014·Molecular Metabolism·Lauren S CsakiKaren Reue
May 9, 2014·The Journal of Biological Chemistry·James M EatonThurl E Harris
Sep 19, 2014·Journal of Lipid Research·Chi-Liang Eric YenMei-I Yen
Sep 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Clara MeanaMaría A Balboa
Jan 18, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Lijuan BiJunying Zhou
Dec 30, 2016·The Journal of Experimental Medicine·Gema LordénMaría A Balboa
Apr 16, 2017·Biochimica Et Biophysica Acta. Biomembranes·Peixiang Zhang, Karen Reue
May 17, 2018·Nature Communications·Terytty Yang LiSheng-Cai Lin
Jul 22, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·George G SchweitzerBrian N Finck
Dec 7, 2018·The Journal of Clinical Investigation·Peixiang ZhangKaren Reue

❮ Previous
Next ❯

Citations

Jun 10, 2020·Brain : a Journal of Neurology·Ana CascalhoRose E Goodchild
Jun 17, 2020·Journal of Lipid Research·Joanna M Kwiatek, George M Carman
Sep 11, 2019·The Journal of Biological Chemistry·Prabuddha DeyGeorge M Carman
Oct 21, 2020·Biomolecules·Robert M SchilkeMatthew D Woolard
Sep 24, 2020·Journal of Lipid Research·Prabuddha DeyGeorge M Carman
Feb 4, 2021·Journal of Lipid Research·Prabuddha DeyGeorge M Carman
Mar 7, 2021·Biomolecules·Polly J Ferguson, Hatem El-Shanti
Mar 7, 2021·International Journal of Environmental Research and Public Health·Tiago MateusSandra Rebelo
Apr 4, 2021·International Journal of Molecular Sciences·Asami WatahikiHiroyuki Inuzuka
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Vineet Choudhary, Roger Schneiter
May 1, 2021·International Journal of Molecular Sciences·Laura BrohéeChristophe Deroanne
May 21, 2021·The Journal of Biological Chemistry·George M Carman
Jul 11, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Dan ChalilKen D Stark

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Related Papers

The Journal of Clinical Investigation
Ira J Goldberg, M Mahmood Hussain
Biochimica Et Biophysica Acta. Biomembranes
Peixiang Zhang, Karen Reue
Yi chuan = Hereditas
Sheng-Qiu TangXiao-Ying Dong
© 2022 Meta ULC. All rights reserved