PMID: 2484576Jul 1, 1989Paper

Mammalian metallothionein

Biological Trace Element Research
J H Kägi, P Hunziker

Abstract

Chemical, spectroscopic, and structural studies have established the metallothioneins (MTs) to be a widely occurring family of polypeptidic bioinorganic structures. They are distinguished by an extremely high metal (Zn, Cd, Cu) and Cys content and by the arrangement of these components in metal-thiolate clusters. By structural criteria the MTs have recently been subdivided into three classes (Fowler et al., Experientia Suppl. 52, 19-22, 1987). Class I MTs include mammalian MTs and related forms. Class II MTs display no such relationships, and Class III MTs are atypical polypeptides made up of repetitive gamma-glutamylcysteinyl units. Amino acid sequences of over 50 MTs are now known. In mammals, over 55% of the residues, including the 20 Cys, are conserved. Mammalian MTs are genetically polymorphous. Thus, in human tissues and cell lines closely related structures of ten functional isoMTs have been determined either by amino acid or nucleotide sequencing. A comparable degree of polymorphism also exists in the rabbit. Mammalian MTs have been inferred to bind a total of seven bivalent metal ions (Me) through thiolate coordination in two separate clusters, i.e., Me(II)3(Cys)9 and Me(II)4(Cys)11. This two-cluster model has now full...Continue Reading

References

Oct 1, 1979·Genetical Research·V Murray, R Holliday
Oct 15, 1977·FEBS Letters·M M Kissling, H R Kägi
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y KojimaJ H Kägi
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C C McCormickJ S Garvey
Jun 1, 1986·Molecular and Cellular Biology·A HeguyM Karin
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M NemerT R Butt
Oct 15, 1985·The Biochemical Journal·P E Hunziker, J H Kägi
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J D Otvos, I M Armitage

❮ Previous
Next ❯

Citations

Jun 10, 2004·Pathology Oncology Research : POR·Rongxian JinBoon-Huat Bay
Jul 1, 1992·The International Journal of Biochemistry·J DunderskiG Matić
Jul 1, 1995·Neurochemistry International·M EbadiR F Pfeiffer
Nov 1, 1994·General Pharmacology·M Ebadi, P L Iversen
Jun 4, 1999·Toxicology Letters·S H GarrettD A Sens
Jul 13, 2006·Journal of Occupational and Environmental Medicine·Megan Weil LatshawBrian Schwartz
May 16, 2000·Environmental Health Perspectives·M A SensD A Sens
Feb 26, 2009·PloS One·Isabella CapelliniRobert A Barton
Jun 30, 2014·Pesticide Biochemistry and Physiology·Anshoo Malhotra, D K Dhawan
Oct 28, 1998·Free Radical Research·M V KumariM Ebadi
Feb 19, 2002·Kidney International·Doyeob KimDonald A Sens
Aug 9, 2011·Molecular Microbiology·Chen DingDennis J Thiele
Mar 15, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Sabina SwierzcekRobert G Price
Mar 19, 2013·Cell Host & Microbe·Chen DingDennis J Thiele
Mar 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Volkan GurelMary Ann Sens
Jun 17, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Scott H GarrettDonald A Sens
Apr 6, 2007·The Journal of Dermatology·Rafid A NajimAhmed R Abu-Raghif
Oct 5, 2006·Experimental Biology and Medicine·Boon-Huat BayPuay-Hoon Tan
May 10, 2000·The Journal of Nutrition·S R Powell

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.