Mammalian parathyroids: morphological and functional implications

Microscopy Research and Technique
P Wild, T Setoguti

Abstract

Fixation with aldehydes is achieved either by immersion or perfusion. The parenchyma of parathyroid glands fixed by immersion consists of dark cells containing a lot of membranes of these organelles which are concerned with hormone secretion, light cells which are poor in these organelles, intermediate forms between the two, and multinuclear syncytial cells. They have been attributed to represent different functional stages of secretory activity, the dark cell being in an active form, the light cell in a resting form. Studies of the parathyroids of mice, rats, rabbits, cats, dogs, pigs, cattle, sheep, goats, and horses employing various fixation protocols clearly demonstrate that light cell variants and multinuclear syncytial cells are formed during improper immersion fixation as a result of membrane disintegration. Parathyroids fixed by perfusion or by immersion in an appropriate fixation medium comprise only one cell type which correspond to the dark chief cell. Parathyroid cells are polar cells bearing some of the rough endoplasmic reticulum in the basal pole, the rest of it, the Golgi complex, and secretory granules in the apical pole. The secretory product is released by exocytosis at the apicolateral domain of the plasma ...Continue Reading

References

Jan 1, 1977·The American Journal of Anatomy·T Setoguti
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Jan 1, 1985·Cell and Tissue Research·P Wild, E M Manser
Oct 1, 1971·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·Y Kameda
May 27, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Moor
Feb 1, 1980·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·T SetogutiK Kato
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Sep 1, 1984·Veterinary Pathology·D J MeutenG V Segre
Apr 1, 1980·Journal of Comparative Pathology·A Oksanen

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Citations

May 29, 2012·Endocrine Pathology·Shuting BaiZhanyong Bing
Jan 16, 2007·Biochemical and Biophysical Research Communications·Stephen J QuinnEdward M Brown
Aug 31, 2018·Journal of Toxicologic Pathology·Annamaria Brändli-BaioccoThomas J Rosol
Feb 11, 1999·The Anatomical Record·J I Haynes

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