Mammalian target of rapamycin as a therapeutic target in oncology

Expert Opinion on Therapeutic Targets
R T Abraham, Christina H Eng

Abstract

The mammalian target of rapamycin (mTOR) has emerged as a validated therapeutic target in cancer and mTOR inhibitors alter tumor cell responses to mitogenic signals and microenvironmental stress. The aims of this review are to describe the mTOR signaling pathway and the rationale for the use of rapamycin analogs and other mTOR inhibitors for oncology indications. This review presents information from recent publications, as well as some more conjectural viewpoints stemming from the early clinical experience with mTOR inhibitors in cancer patients. A thorough understanding of the antitumor mechanisms of the existing mTOR inhibitors will drive the development of effective combination therapies to overcome tumor resistance to these agents. Furthermore, the development of second-generation inhibitors of this critical protein target may yield deeper and broader therapeutic activities in human cancers.

References

Jan 13, 1995·The Journal of Biological Chemistry·C J SabersR T Abraham
Feb 1, 1996·Biochemical Society Transactions·M N Hall
Jun 23, 1997·FEBS Letters·N Pullen, G Thomas
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·P E BurnettD M Sabatini
Nov 6, 1998·Molecular Pharmacology·H HosoiP J Houghton
Aug 10, 1999·Nature·L ChinR A DePinho
Nov 24, 1999·The Journal of Biological Chemistry·S IsotaniK Yonezawa
Dec 2, 1999·Experimental Cell Research·E S Kandel, N Hay
Nov 1, 2000·Cell·T Schmelzle, M N Hall
Mar 10, 2001·Experimental Cell Research·L Simpson, R Parsons
Apr 12, 2001·Genes & Development·A C GingrasN Sonenberg
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·K PodsypaninaR Parsons
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·M S NeshatC L Sawyers
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Apr 23, 2002·Current Biology : CB·Stefanie S Schalm, John Blenis
Sep 21, 2002·Molecular and Cellular Biology·Christine C HudsonRobert T Abraham
Jan 31, 2003·Annals of Human Genetics·D J Kwiatkowski
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Estela Jacinto, Michael N Hall
May 14, 2003·Transplantation Proceedings·S N Sehgal
Sep 18, 2003·Nature Reviews. Cancer·Gregg L Semenza
Jan 20, 2004·Trends in Biochemical Sciences·Yong LiKun-Liang Guan
Mar 19, 2004·Nature·Hans-Guido WendelScott W Lowe
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kenneth A Frauwirth, Craig B Thompson
Apr 23, 2004·Trends in Cell Biology·Ana Maria Cuervo
Jun 15, 2004·Cancer Cell·Mary-Ann Bjornsti, Peter J Houghton
Oct 7, 2004·Nature Cell Biology·Estela JacintoMichael N Hall
Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Feb 23, 2005·Current Biology : CB·Robert T Abraham
May 27, 2005·Seminars in Cancer Biology·Bryan C Fuchs, Barrie P Bode
Jun 11, 2005·Human Pathology·Jan Pieter Albert BaakKjell Løvslett
Jun 16, 2005·Current Opinion in Pharmacology·Deborah A Young, Cheryl L Nickerson-Nutter
Jul 2, 2005·Virchows Archiv : an International Journal of Pathology·Derek John AtkinsStephan Störkel
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evanthia GalanisUNKNOWN North Central Cancer Treatment Group

❮ Previous
Next ❯

Citations

Jun 14, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Huafeng Zhang, Gregg L Semenza
Jun 25, 2009·Cancer Immunology, Immunotherapy : CII·Peter Hersey, Xu Dong Zhang
Sep 29, 2009·Cancer Chemotherapy and Pharmacology·Terence O'ReillyH A Lane
Feb 21, 2009·International Journal of Colorectal Disease·Yan-Jie ZhangJing-Yuan Fang
Jun 1, 2010·ACS Chemical Biology·Erin E Carlson
Jul 1, 2010·The Journal of Antibiotics·Sung Ryeol ParkYeo Joon Yoon
Jan 15, 2010·Nature Medicine·Matthew R JanesDavid A Fruman
Mar 18, 2010·Nature Reviews. Clinical Oncology·Janet Dancey
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P HerseyD Schadendorf
Mar 27, 2009·Carcinogenesis·Daniel A TennantEyal Gottlieb
May 29, 2009·American Journal of Physiology. Renal Physiology·Jian-Kang ChenRaymond C Harris
Jan 14, 2009·Molecular Cancer Therapeutics·Nathan T Ihle, Garth Powis
Jun 6, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Ryan J O DowlingNahum Sonenberg
Sep 26, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marco LionelloG Marioni
May 21, 2014·International Journal of Molecular Sciences·Inderjit DaphuFrits Thorsen
Dec 16, 2011·Clinical Genitourinary Cancer·Robert J AmatoMika Stepankiw
Feb 24, 2010·Molecular Aspects of Medicine·Nathan T Ihle, Garth Powis
Aug 2, 2011·The EMBO Journal·Samuel Peña-LlopisJames Brugarolas
Dec 24, 2010·Molecular Systems Biology·Etienne CaronHiroaki Kitano
Jul 1, 2015·International Journal of Surgery·Monica CapozziUNKNOWN ENETS Center of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
Mar 1, 2012·The Biochemical Journal·Lomon So, David A Fruman
Aug 6, 2011·Cell·Timothy R PetersonDavid M Sabatini
Aug 27, 2013·Seminars in Oncology·Stephen M KeefeW Kimryn Rathmell
Oct 21, 2014·PloS One·Henri Augusto KorkesLeandro De Oliveira
Feb 1, 2017·World Neurosurgery·Xin GengQikai Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.