Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region

Human Pathology
Gaetano MagroMichal Michal

Abstract

Partial monosomy 13q, a chromosomal alteration originally reported in spindle cell lipoma, has also been documented in a few cases of mammary myofibroblastoma. Subsequently, a monoallelic loss of RB1 and FOXO1, located on 13q14, was identified in some cases of cellular angiofibroma, a benign stromal tumor of the lower female genital tract. This cytogenetic finding and the overlapping morphologic and immunohistochemical features shared by spindle cell lipoma, mammary myofibroblastoma, and cellular angiofibroma strongly suggest a histogenetic link among these tumors. Recently, we have emphasized morphologic and immunohistochemical similarities between mammary and vulvovaginal myofibroblastoma. The aim of the present study was to asses if these 2 tumors share the same chromosomal alteration. We studied the chromosome 13q14 region by fluorescence in situ hybridization analysis in a series of mammary and vaginal myofibroblastomas, with a readable signal in 7 of 13 mammary myofibroblastomas and 5 of 7 cases of vaginal myofibroblastomas. Despite histologic variation, most of the mammary (5/7) and vaginal (3/5) myofibroblastomas showed monoallelic deletion of FOXO1 in more than 22% of the cell populations. Our findings confirm that mam...Continue Reading

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Citations

Mar 19, 2014·Pathology, Research and Practice·Anne-Laure TrépantJean-Christophe Noël
Apr 9, 2014·Acta histochemica·Gaetano MagroRosalba Parenti
Sep 23, 2014·Pathology, Research and Practice·Gaetano MagroGiuseppe Angelico
Aug 21, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Rose ChamiPaul Scott Thorner
Jan 16, 2016·Histopathology·Emad A RakhaIan O Ellis
May 1, 2015·Journal of Cutaneous Pathology·John K Schoolmeester, Karen J Fritchie
Jun 9, 2016·BMC Clinical Pathology·Mouna KhmouZaitouna Alhamany
Jun 9, 2016·Journal of Pathology and Translational Medicine·Soyeon AnKyung-Ja Cho
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Mar 13, 2014·Reproductive Sciences·Hiroshi KobayashiYuki Yamada
Mar 20, 2018·International Journal of Surgical Pathology·Christopher J SchwartzFarbod Darvishian
Oct 12, 2017·International Journal of Surgical Pathology·Kartik ViswanathanSyed Hoda
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Mar 19, 2019·Frontiers in Endocrinology·Consolato SergiSong-Mei Liu
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Apr 4, 2021·Diagnostics·Sasha LibbrechtDavid Creytens
Jul 30, 2021·Virchows Archiv : an International Journal of Pathology·Emad A RakhaCecily Quinn
Aug 14, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ryosuke TajiriMasanori Hisaoka

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