PMID: 11921185Mar 29, 2002Paper

Mammary gland carcinogenesis by food-derived heterocyclic amines: metabolism and additional factors influencing carcinogenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

Environmental and Molecular Mutagenesis
E G Snyderwine

Abstract

The heterocyclic amines (HCAs) are a family of mutagenic/carcinogenic compounds found in cooked meats. Several HCAs are mammary gland carcinogens in rats. Of these compounds, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the major one present in the human diet. This report reviews the studies on rat mammary gland carcinogenesis by HCAs; discusses what is currently known regarding mechanisms of mammary gland carcinogenesis of PhIP, especially the significance of metabolic processing; and further highlights the evidence for the possible role of PhIP in human breast cancer.

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Citations

May 10, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Lynnette R FergusonPhilip Kestell
Aug 7, 2008·The Journal of Pharmacology and Experimental Therapeutics·Connie Cheung, Frank J Gonzalez
Oct 25, 2011·Annual Review of Pharmacology and Toxicology·Suzanne E FentonRetha R Newbold
May 8, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kana WuEunyoung Cho
Dec 3, 2014·Meat Science·Niki MouroutiDemosthenes B Panagiotakos
Sep 10, 2014·International Journal of Food Sciences and Nutrition·Niki MouroutiDemosthenes B Panagiotakos
Oct 6, 2005·Nutrition and Cancer·Kin-Yoke WongAdeline Seow

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