Mammary leukocyte response to drug therapy

Journal of Dairy Science
S C NickersonG Ziv

Abstract

The possibility exists that antibiotics and anti-inflammatory agents will be used indiscriminately in attempts to reduce leukocyte or somatic cell counts in mammary secretions to conform with Interstate Milk Shippers quality standards for raw milk to be implemented July 1, 1986. Recent in vivo studies evaluating the effect of intramammary drug injection on milk leukocytes confirmed previous in vitro investigations demonstrating that certain drugs have a significant effect on leukocyte antimicrobial activity. Antibiotics commonly included in commercial infusion products used in this country such as penicillin G, semisynthetic penicillins, the mycins, cephalosporins, and sulfonamides did not affect leukocyte function. However, some drugs were detrimental, notably chloramphenicol, tiamulin, tetracycline, gentamicin, rifampicin, amikacin, and nitrofurantoin. In vitro investigations on the use of anti-inflammatory agents demonstrated that methylprednisolone had a stabilizing effect on leukocytes by maintaining viability and reducing degranulation, whereas flumethasone was detrimental to cell viability. The nonsteroid agent, ibuprofen, decreased viability and increased degranulation but also increased phagocytosis and bacterial killi...Continue Reading

References

Jul 1, 1978·Infection and Immunity·L A BoxerR L Baehner
Jul 1, 1979·The Journal of Surgical Research·M M FuenferH C Polk
Dec 1, 1978·The Journal of Clinical Investigation·J I GallinE Schiffmann
Nov 1, 1979·Infection and Immunity·J McGillen, J Phair
Apr 1, 1977·Antimicrobial Agents and Chemotherapy·A Forsgren, D Schmeling
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·S S Kaplan, S Finch
Dec 1, 1972·Proceedings of the Society for Experimental Biology and Medicine·M R CooperC E McCall
Jul 15, 1981·Developmental Biology·J M SnyderJ M Johnston
Aug 1, 1964·The Journal of Experimental Medicine·A S WEISBERGERS ARMENTROUT

❮ Previous
Next ❯

Citations

Apr 22, 2003·Journal of Dairy Science·S A Wagner, M D Apley
Sep 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·M SandholmS Pyörälä
Sep 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·S Pyörälä
Oct 1, 1992·Zentralblatt für Veterinärmedizin. Reihe A·S HuZ Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.