Abstract
We present an extensive immunohistochemical analysis of 7 mammary sarcomas that did not fit into any specific soft tissue sarcoma category. Histologically, they were composed of spindle cells with highly pleomorphic nuclei and abundant mitoses. Our immunohistochemical antibody panel included pan-cytokeratin (CK), basal cell type CKs (34betaE12, CK5/6, CK14, CK17) and vimentin antibodies, antibodies to established (SMA, CD10, p63, S-100, maspin, calponin, GFAP, SM-myosin), and novel (CD29, 14-3-3sigma) myoepithelial markers, as well as antibodies to CD34, desmin, h-caldesmon, steroid receptors (estrogen, progesterone, androgen), and EGFR (Her-1). Whereas CKs, CD34, desmin, and h-caldesmon were not expressed, all tumors were positive for CD10 and vimentin. CD29 and SMA were observed in 3 cases each (43%), and p63 and calponin in 2 cases each (29%). Other myoepithelial markers and steroid receptors were absent, except androgen receptors, which were expressed in one sarcoma. Five sarcomas showed positivity for EGFR. The distinction of specific, histogenetically defined sarcoma entities (such as leiomyosarcoma, angiosarcoma, liposarcoma) from NOS-type sarcoma with CD10 expression is usually clear-cut because the former exhibit a cha...Continue Reading
References
Sep 1, 1990·Cancer·S G PollardH H Thompson
Jan 1, 1989·Breast Cancer Research and Treatment·P TerrierG Contesso
Apr 1, 1985·Annals of Surgery·C D CalleryD W Kinne
Nov 1, 1996·Histopathology·J S Silverman, A Tamsen
Apr 20, 1999·Human Pathology·K WatanabeT Suzuki
Feb 8, 2000·International Journal of Radiation Oncology, Biology, Physics·T S McGowanT Panzarella
Nov 9, 2000·American Journal of Clinical Pathology·K M CeballosJ X O'Connell
Jan 3, 2001·Histopathology·T Moore, A H Lee
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·P G ChuK L Chang
Sep 5, 2001·Histopathology·W G McCluggageP Maxwell
Apr 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Suzuko MoritaniTakanori Hattori
Feb 27, 2003·The American Journal of Surgical Pathology·Ana M Burga, Fattaneh A Tavassoli
Oct 14, 2003·American Journal of Surgery·D Kay BlanchardJohn H Donohue
Nov 11, 2003·Human Pathology·Barbara DunneIan O Ellis
Jan 31, 2004·Gynecologic Oncology·Xue-Qiong ZhuYu-Zhong Wu
Jun 10, 2004·British Journal of Cancer·C AdemA G Nascimento
Aug 31, 2004·Journal of Surgical Oncology·Manoj PandeyBalakrishnan Rajan
Nov 27, 2004·Asian Journal of Surgery·Ashraf F HefnyFikri M Abu-Zidan
Feb 24, 2005·The American Journal of Surgical Pathology·Sebastian LeiblFarid Moinfar
Jun 25, 2005·Journal of Clinical Pathology·S Leibl, F Moinfar
Jun 29, 2005·Histopathology·H KalekouC S Papadimitriou
Citations
Feb 3, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Tomohiro HarukiIwao Taniguchi
May 13, 2009·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Gary M K TseHui-Juan Shi
Nov 28, 2009·Nature Reviews. Clinical Oncology·Britta Weigelt, Jorge S Reis-Filho
Feb 28, 2008·The American Journal of Surgical Pathology·Philip M CarpenterSharon P Wilczynski
Jul 25, 2009·Pathology International·Davor TomasBozo Kruslin
Mar 15, 2013·Journal of Clinical Pathology·Andrew H S Lee
Jan 30, 2013·Diagnostic Pathology·Guang-Zhi YangHua-Ye Ding
May 3, 2011·Polish Journal of Veterinary Sciences·K M PawłowskiM Król
Mar 4, 2008·Histopathology·S Shousha
Oct 14, 2014·Case Reports in Pathology·Katsumi KitoKeizo Furuya
Nov 6, 2008·Veterinary Pathology·H WensmanE Hellmén
Feb 16, 2012·International Journal of Surgical Pathology·Gitika AggarwalSuash Sharma
Sep 18, 2018·Histopathology·Sanpeng XuYaqi Duan
Jan 4, 2008·Histopathology·A H S Lee
Sep 16, 2010·Histopathology·Renata Fraga IanezSilvia Vanessa Lourenço
Oct 3, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Meenakshi BansalXi Wang
Mar 18, 2020·Journal of Cutaneous Pathology·Claudia Mestre-Alagarda, Carlos Monteagudo
Dec 9, 2014·Asia-Pacific Journal of Clinical Oncology·Hong ZhuLin-Hong Song
Oct 29, 2020·Histopathology·Emad A RakhaRaluca Mihai
Feb 5, 2021·Cancers·Zeger RijsPieter B A A van Driel
Dec 8, 2009·Archives of Pathology & Laboratory Medicine·Ilan WeinrebDavid M Hwang
Apr 7, 2011·Archives of Pathology & Laboratory Medicine·Rajan DewarAllen M Gown
Jul 30, 2021·Virchows Archiv : an International Journal of Pathology·Emad A RakhaCecily Quinn
Jul 30, 2021·Journal of Clinical Pathology·Emad RakhaCecily Quinn
Mar 1, 2012·Pathology, Research and Practice·Seyran YigitDemet Etit