Mammary renin-angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Maria del Pilar CarreraJosé Manuel Martínez-Martos

Abstract

Angiotensin II in particular and/or the local renin-angiotensin system in general could have an important role in epithelial tissue growth and modelling; therefore, it is possible that it may be involved in breast cancer. In this sense, previous works of our group showed a predominating role of angiotensin II in tumoral tissue obtained from women with breast cancer. However, although classically angiotensin II has been considered the main effector peptide of the renin-angiotensin system cascade, several of its catabolism products such as angiotensin III and angiotensin IV also possess biological functions. These peptides are formed through the activity of several proteolytic regulatory enzymes of the aminopeptidase type, also called angiotensinases. The aim of this work was to analyse several specific angiotensinase activities involved in the renin-angiotensin system cascade in mammary tissue from control rats and from rats with mammary tumours induced by N-methyl-nitrosourea (NMU), which may reflect the functional status of their target peptides under the specific conditions brought about by the tumoural process. The results show that soluble and membrane-bound specific aspartyl aminopeptidase activities and membrane-bound glu...Continue Reading

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Citations

Feb 10, 2012·American Journal of Physiology. Endocrinology and Metabolism·Nadja GrobeMariana Morris
May 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Isabel Rodríguez-GómezFélix Vargas
Feb 20, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Javier Carmona-CortésFélix Vargas
Dec 20, 2011·Endocrine-related Cancer·Gavin P VinsonJohn R Puddefoot
Dec 18, 2014·Integrative Cancer Therapies·María Dolores Ruíz-SanjuanMaría Jesús Ramírez-Expósito
Nov 8, 2020·Cancers·María Jesús Ramírez-ExpósitoJose Manuel Martínez-Martos
Mar 24, 2021·Molecular and Cellular Endocrinology·Flávia Sardela de MirandaNaima Moustaid-Moussa

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