Mammographic and ultrasonographic comparison between intraoperative radiotherapy (IORT) and conventional external radiotherapy (RT) in limited-stage breast cancer, conservatively treated

European Journal of Radiology
Sabino Walter Della SalaSalvatore Mussari

Abstract

Assess mammographic and echographic modifications in mild cases of breast cancer (suitable for conservative surgery) after intraoperatory radio treatment (IORT) as opposed to conventional post-operative radiotherapy (RT). We report data from 45 patients in each group (IORT and RT). All patients were examined using the same mammographic and ecographic equipment at 6, 12 and 24 months after treatment. We focused on structural alterations, edema and others, and quantified them using pre-established (unbiased) protocols. Both patient examination and subsequent assessment of the results were performed by radiologists with exepertise in breast cancer evaluation. At 6 months, IORT patients showed slightly more pronounced structural distortions and oedema than RT patients; these differences became more apparent at 12 months, with the addition of fat necrosis and/or calcifications. These alterations were evident and consistent under both mammographic and ecographic examination, and became even more pronounced at 24 months. At this stage, RT patients showed minimal alterations of the tissue (apart from normal post-surgical scarring), whereas IORT patients showed virtually no improvement over the preceding 12-month period. We show radiolo...Continue Reading

References

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Citations

Oct 26, 2012·AJR. American Journal of Roentgenology·Silvia PradellaStefano Colagrande
Dec 18, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B ElsbergerA Evans
Sep 3, 2014·International Journal of Breast Cancer·Harriet B Eldredge-HindyNicole L Simone
Aug 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Ross P PetersenIvo A Olivotto
May 3, 2012·Radiology Research and Practice·Ronald RiveraDennis R Holmes
Nov 17, 2009·The Breast : Official Journal of the European Society of Mastology·M RuchK Wasser

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