Mammographic density and breast cancer risk by family history in women of white and Asian ancestry

Cancer Causes & Control : CCC
Gertraud MaskarinecCeline M Vachon

Abstract

Mammographic density, i.e., the radiographic appearance of the breast, is a strong predictor of breast cancer risk. To determine whether the association of breast density with breast cancer is modified by a first-degree family history of breast cancer (FHBC) in women of white and Asian ancestry, we analyzed data from four case-control studies conducted in the USA and Japan. The study population included 1,699 breast cancer cases and 2,422 controls, of whom 45% reported white (N = 1,849) and 40% Asian (N = 1,633) ancestry. To standardize mammographic density assessment, a single observer re-read all mammograms using one type of interactive thresholding software. Logistic regression was applied to estimate odds ratios (OR) while adjusting for confounders. Overall, 496 (12%) of participants reported a FHBC, which was significantly associated with breast cancer risk in the adjusted model (OR 1.51; 95% CI 1.23-1.84). There was a statistically significant interaction on a multiplicative scale between FHBC and continuous percent density (per 10 % density: p = 0.03). The OR per 10% increase in percent density was higher among women with a FHBC (OR 1.30; 95% CI 1.13-1.49) than among those without a FHBC (OR 1.14; 1.09-1.20). This patter...Continue Reading

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Oct 28, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F IslamiM Weiss
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Dec 29, 2020·International Journal of Cancer. Journal International Du Cancer·Soyeoun Kim, Boyoung Park
Aug 4, 2021·Breast Cancer Research and Treatment·Tara M Friebel-KlingnerAnne Marie McCarthy

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