Mammography behavior after receiving a negative BRCA1 mutation test result in the Ashkenazim: a community-based study

Genetics in Medicine : Official Journal of the American College of Medical Genetics
S E PlonC S Richards

Abstract

To define the impact of a negative BRCA1 test result on subsequent breast cancer screening behavior in women. Longitudinal study of a community-based sample of Ashkenazi Jews offered testing for the 185delAG BRCA1 mutation in 1996. Of 309 participants, 118 women were mutation negative, of average risk (based on family history of cancer), unaffected with breast cancer, and provided complete data at baseline, and Year 1 and Year 2 follow-up questionnaires. Women age 50 and older had 91.7% compliance with mammography for the year prior to entry (baseline), 88.3% during Year 1, 91.7% during Year 2 (no significant change; P = 0.775). Women under age 50 demonstrated an increase in mammography (49.2% at baseline, 62.7% Year 1, and 67.1% Year 2; P = 0.035). Both groups demonstrated significant decreases in breast cancer worry and perceived risk. Logistic regression analysis on having a mammogram at Year 2 showed that age, physician recommendation, worry, and perceived risk were all significant. Receipt of negative BRCA1 test results in a cohort of Ashkenazi Jewish women did not have a negative impact on mammography behavior 2 years after genetic testing.

References

May 1, 1990·Preventive Medicine·C LermanP F Engstrom
Oct 1, 1995·Nature Genetics·D E Goldgar, P R Reilly
Jul 7, 1993·Journal of the National Cancer Institute·C LermanP Engstrom
Apr 16, 1997·Journal of the National Cancer Institute·P Eastman
May 15, 1997·The New England Journal of Medicine·J P StruewingM A Tucker
May 21, 1997·Journal of the National Cancer Institute·P Eastman
Jun 8, 1999·American Journal of Public Health·M D SchwartzC Lerman

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Citations

Feb 5, 2004·Social Science & Medicine·Catharine WangS D Sofia D Merajver
Jul 15, 2009·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Jada G HamiltonAnne Moyer
Jan 18, 2005·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Susan LaRusseNorman R Relkin
Dec 19, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·June A PetersMark H Greene
Aug 13, 2013·Journal of Community Genetics·Kai Insa Schneider, Jörg Schmidtke
Jul 9, 2011·Thrombosis Research·Martha L LouzadaPhilip S Wells
Mar 11, 2006·Cancer Genetics and Cytogenetics·Henry T LynchGordon Gong
Mar 3, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer CullenJeanne S Mandelblatt
Jul 11, 2002·Obstetrics and Gynecology Clinics of North America·Inbal M Barnes-Kedar, Sharon E Plon

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