Mammosomatotroph cell adenoma of the human pituitary: a morphologic entity

Virchows Archiv. A, Pathological Anatomy and Histopathology
E HorvathC Ezrin

Abstract

Nine cases of a hitherto undescribed morphologic entity, termed mammosomatotroph cell adenoma of the human pituitary, are reported. These tumors, occurring mostly in men, are invariably associated with acromegaly (or gigantism) and high-normal or slightly elevated blood prolactin levels, and it cannot be distinguished clinically from well-differentiated growth hormone cell or mixed growth hormone cell-prolactin cell adenomas. They show a slow growth rate and usually exhibit a diffuse pattern and intense cytoplasmic acidophilia by histology. The immunoperoxidase technique detects both growth hormone and prolactin within the same cells. Electron microscopy reveals monomorphous tumors with a fine structure markedly similar to that of well-differentiated, densely granulated growth hormone cell adenomas. An added feature and diagnostic marker of mammosomatotroph cell adenoma is the presence of extracellular deposits of secretory material. One tumor shows a marked abnormality of hormone packaging and storage, resulting in the cytoplasmic accumulation of pleomorphic bodies containing semicrystalline secretory material.

References

May 5, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·A M Landolt, V Rothenbühler
Apr 1, 1978·The Journal of Clinical Endocrinology and Metabolism·G PelletierJ Hardy
Jan 1, 1974·Cell and Tissue Research·I E StratmannE A Sellers
Jan 1, 1980·Journal of Gerontology·K KovacsC Ezrin
Jan 1, 1980·European Journal of Applied Physiology and Occupational Physiology·K H Kroemer, W S Marras
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·J TrouillasM P Dubois
Jan 1, 1980·Virchows Archiv. A, Pathological Anatomy and Histology·T KameyaR Demura

❮ Previous
Next ❯

Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·M RiedelD K Lüdecke
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·R Y Osamura, K Watanabe
Mar 1, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·I S KomolovS Iu Kasumova
Oct 1, 1995·Endocrine Pathology·Bernd W. ScheithauerDudley H. Davis
Sep 1, 1988·Pathology, Research and Practice·R V Lloyd
Apr 1, 1988·Journal of Neurosurgery·D L BarrowG T Tindall
Oct 10, 1998·Journal of Endocrinological Investigation·M C VantyghemM Mazzucca
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C Zurschmiede, A M Landolt
Nov 11, 1992·The American Journal of the Medical Sciences·L S BlevinsG S Wand
Jun 1, 1991·Pathology, Research and Practice·T Kameya, S Furuhata
Sep 1, 1988·Pathology, Research and Practice·K Kovacs
Nov 1, 1983·Clinics in Endocrinology and Metabolism·S L Asa, K Kovacs
Nov 1, 1989·Trends in Endocrinology and Metabolism : TEM·K KovacsT Sano
Apr 15, 2003·Neurosurgery Clinics of North America·Naoko SannoBernd W Scheithauer
Aug 1, 1986·Clinics in Endocrinology and Metabolism·B W ScheithauerE R Laws
Jan 1, 1999·Neuropathology : Official Journal of the Japanese Society of Neuropathology·H KamitaniT Kubo
Jan 15, 1992·Microscopy Research and Technique·E Horvath, K Kovacs
Nov 1, 1985·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·H S Smyth
May 1, 1990·Journal of Endocrinological Investigation·G Giannattasio, M Bassetti
Oct 1, 1987·Histopathology·A M McNicol
Sep 30, 2017·British Journal of Neurosurgery·Ashwin KumariaIain J Robertson
Jan 1, 1994·Ultrastructural Pathology·M Arnesen, B W Scheithauer
Jun 3, 2021·Journal of Clinical Medicine·Sylvia L Asa, Shereen Ezzat
Sep 10, 2021·Frontiers in Endocrinology·Muhammad Rahmad RoyanRomain Fontaine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.