Man and the Microbiome: A New Theory of Everything?

Annual Review of Clinical Psychology
Mary I ButlerTimothy G Dinan

Abstract

The gut microbiome is implicated in the pathophysiology of a wide range of psychological disorders. Preclinical studies have provided us with key insights into the mechanisms by which the microbiome influences bidirectional gut-brain communication. There are many signaling pathways involved, including the hypothalamic-pituitary-adrenal axis, immune modulation, tryptophan and serotonin metabolism, bile acid transformation, microbial production of neuroactive compounds, and regulation of the endocannabinoid system. The complex and widespread influence of the microbiome on many physiological and psychological processes has generated a keen interest in its therapeutic potential for depression, anxiety, autism, and other psychiatric disorders. It has been shown that the microbiome composition of people suffering with such conditions differs significantly from that of healthy controls, and although the area is in its infancy, interventional studies that alter a person's microbiome through the use of probiotics, prebiotics, or dietary change can alleviate psychopathological symptoms.

References

Feb 1, 1986·Neurochemical Research·L R Hegstrand, R J Hine
Jul 1, 1988·Journal of Cellular Physiology·P H NaccacheS R McColl
Nov 1, 1995·Journal of Psychosomatic Research·A M Van Hemert
May 8, 1997·Biochemical and Biophysical Research Communications·J A BoniniD F Steiner
Aug 2, 2000·Journal of Child Neurology·R H SandlerH M Wexler
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F Holsboer
Nov 9, 2000·Neurology·A KirchnerH O Handwerker
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·H A SackeimR R Goodman
Aug 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sydney M FinegoldAjay Kaul
Sep 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Robert Schwarcz, Roberto Pellicciari
Mar 31, 2004·Brain, Behavior, and Immunity·Ronald P A GaykemaMark Lyte
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Aug 11, 2004·Human Psychopharmacology·Sinead M O'BrienTimothy G Dinan
Nov 6, 2004·Applied and Environmental Microbiology·Yuli SongSydney M Finegold
Jan 5, 2005·Trends in Pharmacological Sciences·John F Cryan, Klemens Kaupmann
Aug 17, 2005·FEMS Microbiology Reviews·Máire BegleyColin Hill
Nov 22, 2005·Journal of Lipid Research·Jason M RidlonPhillip B Hylemon
Jul 5, 2006·EMBO Reports·Ann M O'Hara, Fergus Shanahan
Jul 26, 2006·The American Journal of Gastroenterology·Peter J WhorwellEamonn M M Quigley
Sep 1, 2006·Expert Reviews in Molecular Medicine·Jon P RuddickChristopher A Lowry
Sep 2, 2006·Biological Psychiatry·Frederick A SchroederSchahram Akbarian
Sep 6, 2006·Journal of Affective Disorders·Aye-Mu MyintBrian Leonard
Oct 20, 2006·Current Opinion in Pharmacology·Eero CastrénTomi Rantamäki
Dec 8, 2006·European Journal of Clinical Nutrition·D BentonA Brown
Dec 13, 2006·Nature Medicine·Christel RousseauxPierre Desreumaux
May 1, 2008·The AAPS Journal·Vadivel GanapathyPuttur D Prasad
Nov 18, 2008·Journal of Neuroimmunology·Rongzhen ZhangMichael S McGrath
Jan 24, 2009·Inflammatory Bowel Diseases·Lesley A GraffCharles N Bernstein
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·William R WikoffGary Siuzdak
May 23, 2009·Prostaglandins & Other Lipid Mediators·Atsuhiko IchimuraGozoh Tsujimoto
Jul 28, 2009·Annual Review of Medicine·Miles BergerBryan L Roth
Aug 14, 2009·Autonomic Neuroscience : Basic & Clinical·Helen E Raybould
Nov 21, 2009·Gait & Posture·Affendi Haris PhuahMark W Creaby
Jan 26, 2010·Neuroscience Letters·Enzo EmanuelePierluigi Politi

❮ Previous
Next ❯

Citations

Jan 4, 2020·Radiation Research·Carli B JonesKaren S Sfanos
Sep 17, 2020·Expert Opinion on Biological Therapy·Varun S Wakade, Pravin Shende
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Bruno A Aguilar-LópezFrancisco Javier Sánchez-García
Mar 3, 2020·Frontiers in Aging Neuroscience·Patrizia GiannoniNicola Marchi
Sep 29, 2020·Frontiers in Endocrinology·Els van der GootEddy A van der Zee
Jul 9, 2020·Nutrients·Dinyadarshini JohnsonLearn-Han Lee
Dec 29, 2020·Journal of Neurochemistry·Rubén García-CabrerizoJohn F Cryan
Jun 12, 2020·Neuroscience and Biobehavioral Reviews·Golnaz Tabibnia
Feb 1, 2021·Brain, Behavior, and Immunity·A M HamiehF Marchand
Nov 13, 2020·World Journal of Gastroenterology : WJG·Jian-Hong DingJing-Yu Xu
Jan 29, 2021·Journal of Clinical Medicine·Anujit SarkarMaureen Groer
Sep 2, 2020·Trends in Molecular Medicine·Terri A deRoon-CassiniCecilia J Hillard
Mar 25, 2021·Journal of Cosmetic Dermatology·Jianbiao He, Yan Jia
Oct 23, 2020·Chemical Reviews·Christopher P HopperBinghe Wang
Jun 11, 2021·Frontiers in Immunology·Qiang DongChengcheng Jin
Apr 6, 2020·Food Research International·Iramaia Angelica Neri-Numa, Glaucia Maria Pastore
Aug 17, 2021·Health Promotion Journal of Australia : Official Journal of Australian Association of Health Promotion Professionals·Rob DeSalleRod Kennett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

F1000Research
Eamonn M M Quigley, Prianka Gajula
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Bonnie L Hylander, Elizabeth A Repasky
© 2022 Meta ULC. All rights reserved