Man-Specific, GalNAc/T/Tn-Specific and Neu5Ac-Specific Seaweed Lectins as Glycan Probes for the SARS-CoV-2 (COVID-19) Coronavirus

Marine Drugs
Annick BarrePierre Rougé


Seaweed lectins, especially high-mannose-specific lectins from red algae, have been identified as potential antiviral agents that are capable of blocking the replication of various enveloped viruses like influenza virus, herpes virus, and HIV-1 in vitro. Their antiviral activity depends on the recognition of glycoprotein receptors on the surface of sensitive host cells-in particular, hemagglutinin for influenza virus or gp120 for HIV-1, which in turn triggers fusion events, allowing the entry of the viral genome into the cells and its subsequent replication. The diversity of glycans present on the S-glycoproteins forming the spikes covering the SARS-CoV-2 envelope, essentially complex type N-glycans and high-mannose type N-glycans, suggests that high-mannose-specific seaweed lectins are particularly well adapted as glycan probes for coronaviruses. This review presents a detailed study of the carbohydrate-binding specificity of high-mannose-specific seaweed lectins, demonstrating their potential to be used as specific glycan probes for coronaviruses, as well as the biomedical interest for both the detection and immobilization of SARS-CoV-2 to avoid shedding of the virus into the environment. The use of these seaweed lectins as r...Continue Reading


Dec 19, 1972·Biochemistry·K D Hardman, C F Ainsworth
May 22, 1998·Journal of Molecular Biology·F Melo, E Feytmans
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Mar 5, 2003·Biochemistry·Heidi R BokeschMichael R Boyd
Apr 30, 2003·Antiviral Research·Laura G BarrientosMichael R Boyd
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Barry R O'KeefeMichael R Boyd
Jul 21, 2004·Journal of Computational Chemistry·Eric F PettersenThomas E Ferrin
Dec 23, 2004·The Journal of Biological Chemistry·Toshiyuki MoriMichael R Boyd
Nov 23, 2005·Bioinformatics·Konstantin ArnoldTorsten Schwede
Jul 1, 2006·The Journal of Biological Chemistry·François HelleJean Dubuisson
Jul 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Evelyne DerelleHervé Moreau
Jul 27, 2007·The Journal of Biological Chemistry·Tadashi SatohSoichi Wakatsuki
Dec 8, 2010·Bioinformatics·Pascal BenkertTorsten Schwede
Jun 1, 2011·Nucleic Acids Research·Aurélien GrosdidierOlivier Michielin
Aug 11, 2011·Structure·Leonardus M I Koharudin, Angela M Gronenborn
Aug 7, 2012·Applied and Environmental Microbiology·Jong Won HanGwang Hoon Kim
Jul 19, 2016·Antiviral Research·Jean K MilletSandrine Belouzard

❮ Previous
Next ❯


Mar 7, 2021·Marine Drugs·Orazio Taglialatela-Scafati

❮ Previous
Next ❯

Methods Mentioned

electron microscopy

Software Mentioned

YASARA Structure

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.


Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Deutsche medizinische Wochenschrift
G Hermann
Annals of the New York Academy of Sciences
W C Boyd
Scientific American
N Sharon
British Medical Journal
D L Freed
© 2021 Meta ULC. All rights reserved