PMID: 6105852Jan 1, 1980Paper

Managanese-induced biochemical changes in growing versus adult rats

Archives of Environmental Contamination and Toxicology
G S ShuklaS V Chandra

Abstract

Manganese chloride was administered daily intraperitoneally to growing and adult rats for a period of 30 days to compare certain biochemical parameters in both groups of animals. Marked alterations in the levels of dopamine and norepinephrine in the brain was observed in manganese-treated growing rats. Furthermore, the contents of tyrosine, tryptophan in blood, liver, and brain have been significantly altered in these animals. Identical manganese administration to adult rats had no effect on the contents of tyrosine in liver and brain, nor tryptophan, and dopamine in the brain. Some of the parameters which were altered in the adult rats were less in magnitude compared to the growing animals. The experiments indicated higher susceptibility of the growing rats to the toxic effects of this metal.

References

Feb 1, 1978·Environmental Research·S V Chandra, G S Shukla
Jan 1, 1973·Canadian Journal of Biochemistry·J DonaldsonA Barbeau
Feb 1, 1970·British Journal of Pharmacology·C Sadavongvivad
Jan 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·S P Bagchi, E P Zarycki

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Citations

Nov 1, 1983·Archives of Toxicology·A M Buthieau, N Autissier
Jan 1, 1991·Parasitology Today·J D Barry, C M Turner
Aug 1, 1990·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M N Subhash, T S Padmashree
Aug 8, 2002·Neurotoxicology·R H GwiazdaD R Smith
Aug 6, 2003·Neurotoxicology·Sun Yong BaekYangho Kim
Oct 20, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Farida Louise AssemLeonard Stephen Levy
Nov 6, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christoffer TammSandra Ceccatelli
Feb 1, 1981·Acta Pharmacologica Et Toxicologica·G S Shukla, S V Chandra
Jun 18, 2017·Metallomics : Integrated Biometal Science·Qi YeJonghan Kim
Apr 1, 1981·Acta Pharmacologica Et Toxicologica·S V Chandra, G S Shukla

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