Management and Outcome in Patients with Advanced Juvenile Nasopharyngeal Angiofibroma

Journal of Neurological Surgery. Part B, Skull Base
Vedantam RupaVedantam Rajshekhar

Abstract

Objective  To report the management outcome in a series of patients with advanced juvenile nasopharyngeal angiofibroma (JNA). Design  Retrospective study. Setting  Tertiary care teaching hospital. Participants  Forty-five patients classified as Radkowski stage IIIA or IIIB who presented to us over the past 10 years. Main Outcome Measures  Surgical approaches used and disease free outcomes in patients with advanced JNA. Results  Surgical access for the extracranial component included open (41.9%) and expanded endonasal approaches (58.1%). Craniotomy (16.3%), endoscopy-assisted open approach (7%), or expanded endonasal approach (20.9%) was performed to excise the skull base or intracranial component. Follow up ranged from 4 to 96 months (mean, 20.3 months). Of 35 patients who underwent imaging at the first postoperative follow up, 25 (71.4%) had negative scans. Three symptomatic patients with residual disease underwent endoscopic excision and had negative scans thereafter. Of two others who had radiation therapy, one was disease free and the other lost to follow up. Five others had stable, residual disease. Three patients (8.6%) with recurrent disease underwent surgical excision, of whom two had minimal, stable residual disease. ...Continue Reading

Citations

Dec 14, 2018·Molecular and Clinical Oncology·Massimo RalliAntonio Greco
Dec 7, 2018·Current Opinion in Otolaryngology & Head and Neck Surgery·Giacomo BertazzoniPiero Nicolai

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