Management and outcomes of intraductal papillary mucinous neoplasms

BJS Open
J HippU A Wittel

Abstract

This study evaluated the outcome and survival of patients with radiologically suspected intraductal papillary mucinous neoplasms (IPMNs). IPMN management was reviewed according to Fukuoka risk factors and IPMN localization, differentiating main-duct (MD), mixed-type (MT) and branch-duct (BD) IPMNs. Perioperative results were compared with those of patients undergoing resection of pancreatic ductal adenocarcinoma (PDAC) over the same interval (2010-2014). Overall (OS) and disease-specific (DSS) survival rates were calculated and subgroups compared. Of 142 patients with IPMNs, 26 had MD-IPMN, eight had MT-IPMN and 108 had BD-IPMN. Some 74 per cent of patients with MD- and MT-IPMN were managed by primary resection, whereas this was used in only 27·8 per cent of those with BD-IPMN. The risk of secondary resection and malignant transformation for BD-IPMNs smaller than 20 mm was 8 and 2 per cent respectively during follow-up. Pancreatic head resection of IPMNs was associated with an increased risk of postoperative pancreatic fistula grade B/C compared with resection of PDAC (12 of 33 (36 per cent) versus 41 of 221 (18·6 per cent) respectively; P = 0·010), and greater morbidity and mortality (Clavien-Dindo grade III: 15 of 33 (45 per ...Continue Reading

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Citations

Aug 20, 2020·Arquivos De Gastroenterologia·José Celso ArdenghOtávio Micelli-Neto
Nov 5, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Joseph CarmichealSurinder K Batra
Mar 15, 2020·The Surgical Clinics of North America·Alexander S RosemurgyIswanto Sucandy

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Methods Mentioned

BETA
surgical resection
duodenopancreatectomy
pancreatectomy

Software Mentioned

SPSS®

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