Management and outcomes of patients with recurrent neuroendocrine liver metastasis after curative surgery: An international multi-institutional analysis

Journal of Surgical Oncology
Gaya SpolveratoTimothy M Pawlik

Abstract

We sought to characterize the treatment, as well as define the long-term outcomes, of patients with recurrent neuroendocrine liver metastasis (NELM). Between 1990 and 2014, 322 patients undergoing curative intent liver surgery for NELM were identified from a multi-institutional database. Recurrences were classified as intrahepatic, extrahepatic, and both intra- and extra-hepatic. Overall, median, 1-, 5-, 10-year DFS were 3.1 years, 75.5%, 40.4%, and 32.1%, respectively. After curative intent liver surgery, 209 patients (64.9%) recurred within a median follow-up of 4.5 years, while 113 (35.1%) patients were alive without disease with a follow-up time ≥3 years. The site of recurrence was intrahepatic only (n = 111, 65.7%), extrahepatic only (n = 19, 11.2%), or intra- and extra-hepatic (n = 39, 23.1%). Compared with intrahepatic only recurrence, extrahepatic only, and combined intra- and extra-hepatic recurrence were associated with a worse long-term outcome (10-year OS: intrahepatic only, 42.5%, 95%CI, 24.9-59.0 vs extrahepatic only, 0% and combined intra- and extra-hepatic, 21.5%, 95%CI, 5.3-44.0) (P < 0.001). Most patients were treated with repeat surgery (n = 49, 36.6%), while 34 (23.5%) patients received a somatostatin analog...Continue Reading

References

Jul 1, 1994·The British Journal of Surgery·E W McDermottM F Brennan
Feb 6, 2003·Cancer·Irvin M ModlinMark Kidd
Jul 2, 2003·Journal of the American College of Surgeons·Juan M SarmientoFlorencia G Que
Nov 5, 2003·Annals of Surgical Oncology·Timothy M PawlikSteven A Curley
Apr 24, 2007·AJR. American Journal of Roentgenology·Alexander S HoDaniel B Brown
Dec 7, 2007·Endocrine Pathology·Guido RindiCesare Bordi
Feb 13, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Bolanle AsiyanbolaTimothy M Pawlik
Oct 2, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mechteld C de JongTimothy M Pawlik
Jul 20, 2010·The Surgical Clinics of North America·Srinevas K Reddy, Bryan M Clary
Oct 7, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Peter J KneuertzTimothy M Pawlik
Jan 10, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·K Y GulenchynC Law
Dec 4, 2013·Cancer Treatment Reviews·Juan W ValleStephen Mitchell
Jan 5, 2014·The Lancet Oncology·Andrea FrillingUNKNOWN Working Group on Neuroendocrine Liver Metastases
May 21, 2015·Revista do Colégio Brasileiro de Cirurgiões·Leonardo J ValadaresPaulo Herman
Jun 23, 2015·The Journal of Surgical Research·Gaya SpolveratoTimothy M Pawlik
Aug 10, 2016·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andrea RuzzenenteCalogero Iacono
Feb 2, 2017·Journal of Surgical Oncology·Fabio BaganteTimothy M Pawlik

❮ Previous
Next ❯

Citations

Nov 12, 2017·Reviews in Endocrine & Metabolic Disorders·M ThomaschewskiE von Dobschuetz
Nov 5, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Demetrios MorisTimothy M Pawlik
Jul 22, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Xu-Feng ZhangTimothy M Pawlik
Sep 25, 2019·Journal of Surgical Oncology·Kota Sahara Other Members Of The U S Neuroendocrine Tumor Study Group
Jun 27, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ding-Hui DongTimothy M Pawlik
Dec 12, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Ding-Hui DongTimothy M Pawlik
Mar 16, 2021·Current Oncology Reports·Ashley Kieran Clift, Andrea Frilling
Apr 2, 2021·Journal of Hepato-biliary-pancreatic Sciences·Taku AokiUNKNOWN Japanese Neuroendocrine Tumor Society (JNETS)

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.