Management for squamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience

Auris, Nasus, Larynx
Akihiro HommaSatoshi Fukuda

Abstract

Here we report our experience of patients with squamous cell carcinoma (SCC) of the nasal cavity and ethmoid sinus (NC&ES) together with an analysis of treatment outcomes. A retrospective analysis was performed using data from 25 consecutive patients treated between 2000 and 2012. Four patients were diagnosed with T1, 3 with T2, 4 with T3, 7 with T4a, and 7 with T4b disease. No patient had lymph node metastasis. Twelve patients were treated with surgery with/without radiotherapy and with/without chemotherapy. Of these, 4 underwent endoscopic surgery without an open approach and 3 required an anterior skull base approach. Thirteen were treated with radiotherapy; 1 with radiotherapy alone, and 4 and 8 with intravenous and intra-arterial chemotherapy, respectively. The 5-yr overall survival for T1-3, T4a, and T4b disease was 53.9%, 71.4%, and 29.0%, respectively. The 5-yr disease-specific survival for T1-3, T4a, and T4b disease was 74.1%, 71.4%, and 29.0%, respectively. Our treatment policy for patients with SCC of NC&ES, which basically follows the NCCN guideline, was considered to be appropriate. However, several points in terms of surgery and non-surgical approach remain to be solved through further research.

References

Sep 26, 2003·World Journal of Surgery·John Waldron, Ian Witterick
Dec 19, 2007·Archives of Otolaryngology--head & Neck Surgery·Michael L HinniWolfgang Steiner
Aug 26, 2010·Head & Neck·K Thomas RobbinsCarlos Suárez
Jan 19, 2011·Archives of Otolaryngology--head & Neck Surgery·Ehab Y HannaMerrill Kies
Jul 1, 2011·Japanese Journal of Clinical Oncology·Akihiro HommaSatoshi Fukuda
Feb 6, 2013·The Laryngoscope·Michael L HinniJoseph M Hoxworth

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Citations

Oct 22, 2015·Japanese Journal of Clinical Oncology·Akihiro HommaMasato Fujii
Oct 27, 2017·International Forum of Allergy & Rhinology·Albert H ZhouJean Anderson Eloy
Jul 14, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Emily S NguyenEdward C Kuan

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